冠心病慢性心力衰竭患者的血浆脑钠素水平研究被引量：8

导出

摘要目的对比健康人与冠心病慢性心力衰竭者不同心功能分级者的脑钠素(BNP)水平,建立依据BNP水平诊断心力衰竭的方法。方法采用BIOSITE Triage Meter型检测仪,通过免疫荧光法定量检测BNP,对比健康人与不同心功能分级者的BNP水平。结果心功能正常组BNP为(21±11)pg/ml;心功能Ⅱ级、Ⅲ级、Ⅳ级组BNP水平与心功能正常组比较,差异有统计学意义(P<0.01)。左心室舒张期末内径≤55mm、56～60mm、>60mm组BNP水平比较,差异有统计学意义(P<0.05)。不同BNP水平患者室性心动过速检出事件病例数比较,差异有统计学意义(P<0.05)。结论基础BNP水平高的冠心病患者易并发恶性心律失常。

作者王志华黄佐

机构地区上海闸北区中心医院心内科

出处《中华临床医师杂志（电子版）》 CAS 2010年第8期134-135,共2页 Chinese Journal of Clinicians(Electronic Edition)

基金上海市闸北区卫生局重点课题(ZBZDI01)

关键词冠心病心力衰竭心律失常心性利钠肽脑

分类号 R541.6 [医药卫生—心血管疾病] R541.4 [医药卫生—心血管疾病]

引文网络
相关文献

参考文献10

1Eichhorn EJ.Prognosis determination in heart failure.Am J Med,2001,110(7A):14s-36s.
2Clerico A,Iervasi G,Mariani G.Pathophysiologic relevance of measuring the plasma levels of cardiac natriuretic peptide hormones in humans.Horm Metab Res,1999,31(9):487-498.
3McDonagh TA,Cunningham AD,Morrison CE,et al.Left ventricular dysfunction,natriuretic peptides,and mortality in an urban population.Heart,2001,86(1):21-26.
4Berger R,Huelsman M,Strecker K,et al.B-type natriuretic peptide predicts sudden death in patients with chronic heart failure.Circulation,2002,105(20):2392-2397.
5莫殿军,张晓兰,王晓晖.化学发光免疫分析法检测B 型钠尿肽在心力衰竭诊断中的价值.第五次全国中青年检验医学学术会议论文汇编,北京,2006.
6Maeda K,Tsutamoto T,Wada A,et al.High levels of plasma brain natriuretic peptide and interleukin-6 after optimized treatment for heart failure are independent risk factors for morbidity and mortality in patients with congestive heart failure.J Am Coll Cardiol,2000,36(5):1587-1593.
7胡大一,马长生.心脏病学实践:规范化治疗.心力衰竭的预后评价.北京:人民卫生出版社,2002:102.
8Troughton RW,Frampton CM,Yandle TG,et al.Treatment of heart failure guided by plasma aminoterminal brain natriuretic peptide (N-BNP)concentrations.Lancet,2000,355(9210):1126-1130.
9Jourdain P,Jondeau G,Funck F,et al.Plasma brain natriuretic peptide-guided therapy to improve outcome in heart failure:the STARS-BNP Multicenter Study.J Am Coll Cardiol,2007,49(16):1733-1739.
10Pfisterer M,Buser P,Rickli H,et al.BNP-guided vs symptom-guided heart failure therapy:the Trial of Intensified vs Standard Medical Therapy in Elderly Patients With Congestive Heart Failure (TIME-CHF) randomized trial.JAMA,2009,301(4):383-392.