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哮喘小鼠肺组织Rho、ROCK信号通路与气道炎症及选择性拮抗剂Y-27632的干预

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出处 《中国免疫学杂志》 CAS CSCD 北大核心 2010年第12期1124-1126,共3页 Chinese Journal of Immunology
基金 浙江省自然科学基金项目(No.Y207462)
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参考文献10

  • 1Hashimoto T,Yamashita M,Ohata H et al.Lysophosphatidic acid enhances in vivo infiltration and activation of guinea pig eosinophils and neutrophils via a Rho/Rho-associated protein kinase-mediated pathway[J].J Pharmacol Sci,2003;91(1):8-14.
  • 2Aihara M,Dobashi K,Iizuka K et al.Effect of Y-27632 on release of cytokines from peripheral T cells in asthmatic patients and normal subjects[J].Int Immunopharmacol,2004;4(4):557-561.
  • 3李昌崇,张维溪,陈小芳,谢丽微,何秋莎,胡晓光,林剑,李孟荣,吴荣熙,张正霞.巨噬细胞炎性蛋白1α及其mRNA在哮喘小鼠气道炎症中的作用[J].中华儿科杂志,2004,42(2):90-93. 被引量:19
  • 4Iizuka K,Shimizu Y,Tsukagoshi H et al.Evaluation of Y-27632,a rho-kinase inhibitor,as a bronchodilator in guinea pigs[J].Eur J Pharmacol,2000;406(2):273-279.
  • 5Chiba Y,Sakai H,Misawa M.Augmented acetylcholine-induced translocation of RhoA in bronchial smooth muscle from antigen-induced airway hyperresponsive rats[J].Br J Pharmacol,2001;133(6):886-890.
  • 6Chiba Y,Sakai H,Wachi H et al.Upregulation of rhoA mRNA in bronchial smooth muscle of antigen-induced airway hyperresponsive rats[J].J Smooth Muscle Res,2003;39(6):221-228.
  • 7Hashimoto T,Yamashita M,Ohata H et al.Lysophosphatidic acid enhances in vivo infiltration and activation of guinea pig eosinophils and neutrophils via a Rho/Rho-associated protein kinase-mediated pathway[12].J Pharmacol Sci,2003;91(1):8-14.
  • 8Schaafsma D,bos I S,Zuidhof A B et al.The inhaled Rho kinase inhibitor Y-27632 protects against allergen-induced acute bronchoconstirction,airway hyperresponsiveness and inflammation[J].Am J Physiol Lung Cell Mol Physiol,2008;295:L214-L219.
  • 9Adachi T,Vita R,Sannohe S et al.The functional role of rho and rho-associated coiled-coil forming protein kinase in eotaxin signaling of eosinophils[J].J Immunol,2001;167(8):4609-4615.
  • 10Aihara M,Dobashi K,Iizuka K et al.Effect of Y-27632 on release of cytokines from peripheral T cells in asthmatic patients and normal subjects[J].Int Immunopharmacol,2004;4(4)557-561.

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