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PCOS患者治疗前后血清hs-CRP、IL-6和TNF-α检测的临床意义 被引量:4

Clinical Significance of Changes of Serum hs-CRP,IL-6 and TNF-α Levels After Treatment in Patients with Polycystic Ovary Syndrome
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摘要 目的:探讨了多囊卵巢综合征(PCOS)患者治疗前后血清hs-CRP、IL-6和TNF-α水平的变化及临床意义。方法:应用放射免疫分析和免疫比浊法对31例PCOS患者进行了血清hs-CRP、IL-6和TNF-α检测,并与35名正常人作比较。结果:PCOS患者在治疗前后血清hs-CRP、IL-6和TNF-α水平非常显著地高于正常人组(P<0.01),经治疗后6个月则与正常人组比较无显著性差异(P>0.05),且血清hs-CRP、IL-6和TNF-α水平呈正相关(r=0.6014、0.5982,P<0.01)。结论:检测PCOS患者血清hs-CRP、IL-6和TNF-α水平的变化与疾病的发生和发展密切相关。 Objective To explore the clinical significance of changes of serum hs-CRP, IL-6 and TNF-α levels in patients with polycystic ovary syndrome. Methods Serum hs-CRP (with immunoturbidity method), IL-6, TNF-α (with RIA) levels were determined in 31 patients with polycystic ovary syndrome both before and after six, month’s treatment as well as 35 controls. Results Before treatment, the serum hs-CRP, IL-6 and TNF-α levels in the 31 patients with polycystic ovary syndrome were significantly higher than those in controls (P〈0.01). After treatment for 6 month’s, serum hs-CRP, IL-6 and TNF-α levels were not much different from those in controls (P〉0.05). Serum hs-CRP levels were positive correlate with serum IL-6, TNF-α levels (r=0.6014, 0.5982, P〈0.01). Conclusion Serum hs-CRP, IL-6 and TNF-α levels were correlated to the development of polycystic ovary syndrome (PCOS).
作者 杨文 王颖
出处 《放射免疫学杂志》 CAS 2010年第6期620-621,共2页 Journal of Radioimmanology
关键词 多囊卵巢综合征 超敏C-反应蛋白 白细胞介素-6 肿瘤坏死因子-Α polycystic ovary syndrome (PCOS) hyper sensitive C-reactive protein (hs-CRP) interleukin-6 (IL-6) tumor necrosis factor-α (TNF-α)
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