摘要
pneumocandin B_0(PB_0)是新型棘白菌素类抗真菌药物卡泊芬净的前体。通过离心、溶剂抽提和大孔树脂脱色等方法从丝状真菌Zalerion arboricola发酵液中分离PB_0,得到纯度为77.6%的PB_0粗制品,进一步纯化后,得到纯度为97.2%的PB_0精制品。
Pneumocandin B_0（PB_0） is a precursor of new antifungal drug named caspofungin which belongs to echinocandins.The fermentation of Zalerion arboricola（ATCC 20957） which produces PB_0 was studied.PB_0 was isolated from fermentation broths of Zalerion arboricola by centrifugation,solvent extraction and chromatography of macroporous resin with purity of 77.6%.Its further purification was performed by reverse phase chromatography with purity of 97.2%.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2010年第12期895-897,共3页
Chinese Journal of Pharmaceuticals
基金
国家“重大新药创制”科技重大专项(2009ZX09301-007,2009ZX9302-004,2008ZX09401-005)
