溴苯薄荷醇衍生物和联苯薄荷醇衍生物的合成表征

The Synthesis and Characterization of Bromophenyl Menthol Derivatives and Biphenyl Menthol Derivatives

研究了二环[4.2.0]辛酮中间体薄荷醇衍生物的合成工艺.以(-)-1R,2S,5R-8-(4-溴苯)薄荷醇和(-)-1R,2S,5R-8-联苯薄荷醇为原料,通过酯化反应合成目标化合物,产率分别为94%,95%.其结构经1H NMR,13CNMR,IR,MS和旋光性进行了表征,并对化合物2a和2b的构象稳定性和晶体结构进行了研究.

The Synthesizing Process of bicycle octanone intermediated menthol derivatives was studied.（-）-1R,2S,5R-8-（bromophenyl） menthol and（-）-1R,2S,5R-8-biphenyl menthol was chosen as raw materials,and the compounds mentioned in the title were synthesized by Esterification,the total yield was 94% and 95% respectively.The structures were characterized by 1H NMR,13C NMR,IR,MR and activity.The studies on the Conformational Stability and Crystal Structure of compound 2a and 2b were done.