盐酸多奈哌齐治疗老年人认知功能障碍疗效及安全性观察

Safety and efficacy of donepezil in elderly patients with cognitive impairment

目的观察盐酸多奈哌齐（Donepezil）治疗老年人认知功能障碍的有效性及安全性。方法对517例老年认知功能障碍患者行盐酸多奈哌齐治疗，观察6m。应用简易精神状态检查（MMSE）评定临床疗效，并记录治疗过程中的副反应。结果盐酸多奈哌齐在治疗3m起MMSE评分显著升高，第6月有继续上升趋势（P〈0．05），治疗总有效率为65％。盐酸多奈哌齐对中、重度认知功能障碍者作用显著，入选时MMSE评分与MMSE改善程度呈负相关。盐酸多奈哌齐治疗不良反应轻微，仅有2例患者存在轻度的恶心或胃纳减退，无严重不良反应。结论盐酸多奈哌齐能有效治疗老年认知功能障碍，病情较重的患者MMSE改善更明显；药物治疗不良反应少而轻微。

Objective To investigate the therapeutic effects of donepezil on the cognitive impairment in elderly patients. Method 517 elderly patients with cognitve impairment were enrolled in our study. Patients were treated with donepezil for 6 months. The clinical outcome of donepezil for the patients Was assessed with Mini Mental State Examination （MMSE） before and after the treatment. Results MMSE scores were significantly improved after donepezil treatmerit （P〈0.05） , and the effective rate was 65 %. Donepezil was more effective in patients with moderate to severe cognitive impairment. The most common adverse events were nausea and loss of appetite （0.4 %）, and no sever adverse effect were found during the treatment. Conclusion Donepezil can significantly improve the cognitive impairment in elderly patients.