动态血清孕酮及β-HCG值对早期异常妊娠的临床意义

Clinical significance of dynamic determination of serum progesterone and β-HCG on diagnosis and treatment of early abnormal pregnancy diseases

目的探讨动态血清孕酮(progesterone,P)及β-人绒毛膜促性腺激素(β-human chorionic gonadotrophin,β-HCG)值对早期异常妊娠的临床意义。方法对重庆市人口和计划生育科学技术研究院附属医院135例孕龄6～8周伴阴道出血的病例进行血清P及β-HCG值动态监测,按妊娠结局分为先兆流产继续妊娠组、难免流产组、输卵管妊娠组。结果先兆流产继续妊娠组动态血清P及β-HCG值显著高于难免流产组及输卵管妊娠组,差异有统计学意义(P<0.05)。先兆流产继续妊娠组动态血清β-HCG值呈上升趋势,难免流产组动态血清P及β-HCG值呈下降趋势,输卵管妊娠组血P及β-HCG值明显低于先兆流产继续妊娠组及难免流产组,差异有统计学意义(P<0.05)。结论动态监测血清P及β-HCG值对早期异常妊娠的诊断和治疗有重要的临床意义。

Objective To study clinical value of dynamic determination of serum progesterone and β-human chorionic gonadotrophin（β-HCG） in diagnosis and treatment of early abnormal pregnancy diseases. Methods The levels of serum progesterone and β - HCG were detected continuously in 135 patients with vaginal bleeding which were divided into threatened abortion group, inevitable abortion group and ectopic pregnancy group according to the pregnancy outcomes during gestational age of 6 - 8 weeks. The data of the different indexes detected among these groups were analyzed. Results The levels of serum progesterone and β - HCG in threatened abortion group were significantly higher than those in the other two groups（P 〈0. 05）. The levels of serum progesterone and β - HCG in ectopie pregnancy group were significantly lower than those in the other two groups（ P 〈 0. 05 ）. These results showed descending tendency in threatened abortion group and ascending tendency in threatened abortion group. Conclusion Dynamic determination of serum progesterone and β - HCG levels might be important clinical values in diagnosis and treatment for early abnormal pregnancy.