生物蛋白胶宫颈封堵术治疗早产胎膜早破的临床应用

Clinical application of Fibrin glue on preterm premature rupture of membranes

目的探讨经阴道宫颈封堵生物蛋白胶治疗妊娠28～32周胎膜早破患者的疗效。方法收集成都市第九人民医院2006年6月至2007年12月妊娠28～32周胎膜早破患者26例,治疗组13例采用生物蛋白胶封堵宫颈,对照组13例采用期待疗法,并进行观察性研究。结果治疗组无一例发生宫内感染,平均延长妊娠(29.43±0.14)d,治疗组总有效率为61.5%,明显高于对照组(15.4%),两组比较差异有统计学意义(P<0.05);治疗组较对照组延长孕周时间更长,新生儿死亡率、围生儿并发症发生率更低,两组比较差异有统计学意义(P<0.05)。结论生物蛋白胶应用于未足月胎膜早破可有效延长孕周时间,并且使用安全,不良反应低,但需更多证据。

Objective To study clinical effect of Fibrin glue（FG） in pregnant women with 28 - 32 weeks＇ gestation and preterm premature rupture of membranes （ PPROM ）. Methods Twenty - six pregnant women with 28- 32 weeks＇ gestation and PPROM were collected from June 2006 to December 2007 in Chengdu the Ninth People＇ s Hospital and divided into study group and control group. Thirteen cases were treated by FG in study group and another 13 cases were taken expectant treatment in control group. The perinatal results of two groups were investigated. Results Intra- unterlne infection was none and pregnant period was prolonged （29.43 ±0. 14 ）d in study group. Total effective rate of study group was 61.5% which was higher than that of control group （ 15.4% ） and the difference was significant（ P 〈 0. 05 ）. In study group, Pregnant period was longer and the incidence of neonatal death rate and perinatal complications was lower comparing to that in control group（ P 〈 0. 05 ）. Conclusion FG administrated in midtrimester rupture of the membranes may prolong gestation weeks and improve outcomes with safeness and less adverse reactions that need more study and more evidence of evidence - based medicine.