VEGF-C、VEGFR-3和MMP-2在宫颈癌组织中的表达及其与侵袭、转移的关系

Expressions of VEGF-C,VEGFR-3 and MMP-2 in cervical carcinoma and their relationship with invasion and metastasis of cervical carcinoma tissues

目的:探讨血管内皮生长因子C(VEGF-C)及其受体VEGFR-3和基质金属蛋白酶-2(MMP-2)在人宫颈癌组织中的表达及其与宫颈癌侵袭、转移的关系。方法:采用免疫组化SP法检测11例正常宫颈组织、19例CIN组织、47例宫颈癌组织中的VEGF-C、VEGFR-3和MMP-2的表达,分析表达结果与病理特征的关系。结果:VEGF-C、VEGFR-3和MMP-2在正常宫颈组织、CIN组织及宫颈癌组织中的表达依次增高(P<0.05);伴盆腔淋巴结转移组VEGF-C、VEGFR-3和MMP-2的表达较无淋巴结转移组明显升高(P<0.05);浸润宫颈深度≥1/2组VEGF-C、VEGFR-3和MMP-2的表达明显高于浸润宫颈深度<1/2组(P<0.05)。结论:VEGF-C、VEGFR-3和MMP-2蛋白的异常表达在宫颈癌发生发展及侵袭、转移过程中起重要作用,联合检测这些指标有助于预测宫颈癌组织的侵袭和转移。

Objective：To explore the expressions of vascular endothelial growth factor C（VEGF-C）,VEGF receptor-3（VEGFR-3）and matrix metalloproteinase-2（MMP-2）in human cervical carcinoma and their relationship with invasion and metastasis of cervical carcinoma tissues.Methods：Immunohistochemical S-P method was used to detect the expressions of VEGF-C,VEGFR-3 and MMP-2 in 11 cases of normal cervical tissues,19 cases of CIN tissues and 47 cases of cervical carcinoma tissues,the relationship between expressions of VEGF-C,VEGFR-3 and MMP-2 and pathological characteristics was analyzed.Results：The expression levels of VEGF-C,VEGFR-3 and MMP-2 increased gradually from normal cervical tissues,CIN tissues to cervical carcinoma tissues（P0.05）;the expression levels of VEGF-C,VEGFR-3 and MMP-2 in pelvic lymph node metastasis group were significantly higher than those in non-pelvic lymph node metastasis group（P0.05）;the expression levels of VEGF-C,VEGFR-3 and MMP-2 in cervical invasive depth≥1/2 group were significantly higher than those in cervical invasive depth1/2 group（P0.05）.Conclusion：The abnormal expressions of VEGF-C,VEGFR-3 and MMP-2 may play an important role in the occurrence,development,invasion and metastasis of cervical carcinoma,joint detection of the indexes may help to predict invasion and metastasis of cervical carcinoma tissues.