成纤维细胞生长因子对组织损伤保护作用的研究进展

Research Development on Fibroblast Growth Factor for Protection of Tissue Injury

成纤维细胞生长因子(FGF)在体内分布广泛,对中胚层和神经外胚层来源的组织细胞具有促进分裂增殖和损伤修复的作用。目前已发现的有24种,外源性的aFGF、bFGF、MaFGF是目前应用研究的主要形式,它们通过与组织细胞的表面受体结合,抑制脂质过氧化,拮抗自由基损伤,稳定细胞酶活性,在心血管、肾、神经及肠等器官的机械性或药物性损伤方面发挥保护作用。这提示FGF在组织损伤保护作用方面将有广阔的临床应用前景。

Being distributed widely in human body,24 types of fibroblast growth factors（FGF）have been found by now and their functions are associated with the mitogenic activity and injury repair of tissues and cells originating from mesoderm and neuroectoderm.Recombinant aFGF,bFGF,and MaFGF are present major forms for application researches.They can bind to cellular surface receptors,inhibit lipid over-oxidization,antagonize the damages of free radicals,stabilize cellular enzyme activities,and exert protective effects on the mechanical and medicinal injuries of such organs as heart,blood vessels,kidneys,nerves,intestines and so on.This article suggests that it will have a broad application prospect in tissue injure protection.