期刊文献+

多重耐药鲍曼不动杆菌的抗生素治疗 被引量:6

Antibiotics Treatment of Multidrug-resistant Acinetobacter Baumannii Infections
下载PDF
导出
摘要 近年来,因多重耐药鲍曼不动杆菌造成的院内感染比例明显增加,其对常用的多种抗生素耐药,治疗困难和病死率高,已成为困扰临床医师的难题。在此回顾近年来关于多重耐药鲍曼不动杆菌的抗生素治疗文献,可用于临床治疗的抗生素有舒巴坦、多黏菌素、米诺环素、替加环素和利福平,鉴于这些抗生素临床较少应用,现探讨四种药物的特点和作用,期望为临床和研究提供帮助。 Multidrug-resistant Acinetobacter baumannii(MDR-Ab)leads to increased nosocomial infections proportion in recent years,which resisits to many common antibiotics and cause difficulties for treatment and high mortality.This article reviewed retrospectively recent literature regarding antibiotic treatment of MDR-Ab,the sulbactam,polymyxin B,minocycline,tigecycline and rifampicin are used in clinical treatment according to these reports.Since the four antibiotics are used occasionally in clinical experiences,we discuss the features and effects of these four antibiotics in this paper,which should be helpful to clinical experiences.
出处 《医学综述》 2010年第24期3781-3783,共3页 Medical Recapitulate
关键词 多重耐药鲍曼不动杆菌 抗生素 治疗 Multidrug-resistant Acinetobacter baumannii Antibiotics Treatment
  • 相关文献

参考文献22

  • 1汪复,朱德妹,胡付品,阮斐怡,倪语星,孙景勇,徐英春,张小江,胡云健,艾效曼,俞云松,杨青,孙自镛,简翠,贾蓓,黄文祥,卓超,苏丹虹,魏莲花,吴玲,张朝霞,季萍,王传清,薛建昌,张泓,李万华.2008年中国CHINET细菌耐药性监测[J].中国感染与化疗杂志,2009,9(5):321-329. 被引量:422
  • 2王辉,郭萍,孙宏莉,杨启文,陈民钧,朱元珏,徐英春,谢秀丽.碳青霉烯类耐药的不动杆菌分子流行病学及其泛耐药的分子机制[J].中华检验医学杂志,2006,29(12):1066-1073. 被引量:237
  • 3石岩,刘大为.多重耐药的鲍曼不动杆菌治疗探索[J].中国处方药,2006,5(9):17-20. 被引量:16
  • 4Karageorgopoulos DE,Falagas ME.Currem control and treatment of multidrug-resistant Acinetobacter baumanmi infections[J].Lancet Infect Dis,2008,8(12):751-762.
  • 5Betrosian AP,Frantzeskaki F,Xanthaki A,et al.High-dose ampicillin-sulbactam as an alternative treatment of late-onset VAP from multidrug-resistant Acinetobacter baumannii[J].Scand J Infect Dis,2007,39(1):38-43.
  • 6Higgins PG,Wisplinghoff H,Stefanik D,et al.In vitro activities of the beta-lactamase inhibitors clavulanic acid,sulbactam,and tazobactam alone or in combination with beta-lactams against epidemiologically characterized multidrug-resistant Acinetobacter baumannii strains[J].Antimicrob Agents Chemother,2004,48(5):1586-1592.
  • 7Ko WC,Lee HC,Chiang SR,et al.In vitro and in vivo activity of meropenem and sulbactam against a multidrug-resistant Acineto-bacter baumannii strain[J].J Antimicrob Chemother,2004,53(2):393-395.
  • 8Oliveira MS,Prado GV,Costa SF,et al.Ampicillin/ sulbactam com-pared with polymyxins for the treatment of infections caused by carbapenem-resistant Acinetobacter spp[J].Antimicrob Chemother,2008,61(6):1369-1375.
  • 9Zavascki AP,Goldani LZ,Li J,et al.Polymyxin B for the treatment of multidrug-resistant pathogens:a critical review[J].Antimicrob Chemother,2007,60(6):1206-1215.
  • 10Levin AS,Barone AA,Penco J,et al.Intravenous colistin as thera-py for nosocomial infections caused by multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii[J].Clin Infect Dis,1999,28(5):1008-1011.

二级参考文献43

  • 1王辉,孙宏莉,廖康,陈冬梅,王清涛,王飞燕,陈民钧,朱元珏.北京和广州地区四家医院不动杆菌碳青霉烯酶基因型研究[J].中华检验医学杂志,2005,28(6):636-641. 被引量:121
  • 2张婴元,张敬德,周乐,吴培澄,陈友娣,王宇倩,汪复.头孢哌酮-舒巴坦体外抗菌作用研究[J].中华内科杂志,1995,34(10):676-679. 被引量:52
  • 3王辉,郭萍,孙宏莉,杨启文,陈民钧,朱元珏,徐英春,谢秀丽.碳青霉烯类耐药的不动杆菌分子流行病学及其泛耐药的分子机制[J].中华检验医学杂志,2006,29(12):1066-1073. 被引量:237
  • 4Clinical and I.aboratory Standards Institute(CLSI). Perform ance standards for Antimicrobial susceptibility testing[S]. M100-S17, 2007.
  • 5Clinical and Laboratory Standards Institute (CLSI). Perform anee standards for Antimicrobial susceptibility testing [S]. M100-S19,2009.
  • 6Bratu S, I.andman D, Haag R, et al. Rapid spread of carbapenem resistant Klebsiella pneumoniae in New York City: anew threat to our antibiotic armamentarium[J]. Arch Int Meal.2005,165(12) :1430-1435.
  • 7Endimiani A, Hujer AM, Perez F, et al. Characterization of blaKPC containing Klebsiella pneumoniae isolates detected in different institutions in the eastern USA [J]. J Antimierob Chemother, 2009, 63(3):427-437.
  • 8Jeon BC, Jeong SH, Bae IK, et al. Investigation of a nosocomial outbreak of imipenem resistant Acinetobacter baumannii producing the OXA- 23 β- lactamase in Korea[J]. J Clin Microbiol, 2005, 43(5):2241 -2245.
  • 9NaasT, LevyM, HirschauerC, et al. Outbreak ofcarbapen em resistant Acinetobacter baumannii producing the carbap enemase OXA- 23 in a tertiary care hospital of Pepcete, French Polynesta[J]. J Clin Mierohiol, 2005, 43 (9) : 4826- 4829.
  • 10Waites KB, Dully LB, Dowzicky MJ. Antimicrobial susceptibility among pathogens collected from hospitalized patients in the United States and invitro activity of tigecycline, a new glycylcycline antimicrobial[J]. Antimicrob Agents Chemother, 2006,50(10):3479- 3484.

共引文献795

同被引文献58

  • 1张小江,徐英春,俞云松,杨青,汪复,朱德妹,倪语星,孙景勇,孙自镛,简翠,胡云建,艾效曼,张泓,李万华,贾蓓,黄文祥,王传清,王爱敏,魏莲花,吴玲,卓超,苏丹虹,张朝霞,季萍,徐元宏,熊自忠,沈继录,单斌,杜艳.2009年中国CHINET鲍曼不动杆菌细菌耐药性监测[J].中国感染与化疗杂志,2010,10(6):441-446. 被引量:137
  • 2王辉,郭萍,孙宏莉,杨启文,陈民钧,朱元珏,徐英春,谢秀丽.碳青霉烯类耐药的不动杆菌分子流行病学及其泛耐药的分子机制[J].中华检验医学杂志,2006,29(12):1066-1073. 被引量:237
  • 3石岩,刘大为,许大波,徐英春,陈民均,王辉.泛耐药鲍曼不动杆菌感染临床治疗初探[J].中国感染与化疗杂志,2007,7(1):34-37. 被引量:112
  • 4PELEG AY, SDIFERT H, PATERSON DL. Acinetobacter baumannii: emergence of a successful pathogen [ J ]. Clin Microbiol Rev ,2008,21 (3) :538 - 582.
  • 5MATTHEW AW, FRANKLEN RC, WILLIAM AC, et al. Performance standards for antimicrobial susceptibility testing[ J ]. Sixteenth Infomlation Supplement CLS1,2009,26 (3) :31 -34.
  • 6PATWARDHAN RB, DHAKEPHALKAR PK, NIPHADKAR KB, et al. A study on nosocomkJ pathogens in ICU with special reference to multiresistant. Acinetobacter baumanii harbouring multiple plasmkls [ J ]. Indian .I Med Res, 2008,128 ( 2 ) : 178 - 187.
  • 7Wilcox M, Nathwani D, Dryden M. Linezolid compared with teicoplanin for the treatment of suspected or proven Gram-positive infections [ J ]. J Antimicrob Chemother, 2004,53 : 335-344.
  • 8Moise PA, Forrest A, Birmingham MC, et al. The efficacy and safety of linezolid as treatment for Staphylococcus aureus infectionsin compassionate use patients who are intolerant of, or who have failed to respond to, vancomycin [ J ]. J Antimicrob Chemother, 2002,50 : 1017-1026.
  • 9Neonakis IK, Spandidos DA, Petinaki E. Confronting muhidrug- resistant Acinetobacter baumanii : a review [ J ]. Int J Antimicrob Agents,2011,37:102-109.
  • 10Hern&ndez-Torres A, Garcia-V:izquez E, G6mez J, et al. Carbapenem and multidrug-resistant Acinetobacter baumannii colonisation/infection: epidemiology and factors associated with infection[ J]. Med Clin (Barc) ,2010,135:389-396.

引证文献6

二级引证文献39

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部