偶测血压正常的母系遗传性高血压家系成员24h动态血压分析

Characteristic analysis of 24 h ambulatory blood pressure monitoring in normotensive of maternally inherited essential hypertension pedigrees

目的探讨母系遗传性高血压(MIEH)家系成员中血压正常者的动态血压监测(ABPM)的变化特点及临床意义。方法从13个MIEH家系中选取母系血压正常者76例为研究组,筛选80例无高血压家族史的健康人为对照组,比较两组AB-PM的结果。结果两组24 h、白天和夜间的平均收缩压(SBP)和舒张压(DBP)未超过正常参考标准,但研究组24 h平均脉压、对称动态动脉硬化指数(S-AASI)、动态动脉硬化指数(AASI)均高于对照组(P<0.05)。相对危险度分析显示:动脉硬化与MIEH家族史有关(χ2MH=25.67,P<0.001,OR值为5.142)。结论 MIEH家系的血压正常者ABPM的主要参数值与国人的正常值无差异,但并发动脉硬化是对照组的5.142倍。

Objective To investigate the characteristic and clinical significance of ambulatory blood pressure in normotensive of maternally inherited essential hypertension（MIEH）pedigrees.Methods 76 maternal normotensives from 13 MIEH pedigrees（research group）and 80 clinically healthy persons without family history of essential hypertension（control group）were enrolled.Ambulatory blood pressure monitoring（ABPM）was performed and the blood pressure parameters were compared.Results ABPM show 24 h average systolic blood pressure and diastolic blood pressure of two groups did not exceed normal value range.But the 24 h average pulse pressure,Symmetric ambulatory arterial stiffness index and ambulatory arterial stiffness index of subjects in research group were significantly higher than those of control group（P〈0.05）.Relative risk analysis indicated that arterial stiffness had statistically significant relation with family history of MIEH（χ2MH=25.67,P〈0.001,OR=5.142）.Conclusion Our study showed that the main parameters of ABPM in research group were not different from normal value of Chinese people.But proportion of the subject with arterial stiffness in research group is 5.142 times as control group.