上皮钙依赖黏附素和β-连环蛋白在乳腺髓样癌中的表达及其预后研究

Study on the expression of E-cadherin and β-catenin and its prognosis in medullary breast carcinoma

目的探讨上皮钙依赖黏附素和β-连环蛋白在乳腺髓样癌中的表达及临床意义。方法采用免疫组织化学法检测49例乳腺髓样癌中上皮钙依赖黏附素和β-连环蛋白的表达情况。结果上皮钙依赖黏附素和β-连环蛋白表达阳性率在乳腺典型髓样癌中高于非典型髓样癌,并且两者的表达呈正相关(P<0.05)。上皮钙依赖黏附素和β-连环蛋白表达阳性率与淋巴结转移及临床分期显著相关(P<0.05),而与患者年龄、肿瘤大小及是否远处转移无关(P>0.05)。结论上皮钙依赖黏附素和β-连环蛋白的表达差异是影响乳腺髓样癌预后的重要原因。

Objective To investigate the clinical significance of E-cadherin and β-catenin expression in medullary breast carcinoma.Methods The immunohistochemical staining method was used to evaluate the positivity of E-cadherin and β-catenin in 49 cases medullary breast carcinoma.Results The positive rate of E-cadherin and β-catenin expression was higher in typical medullary breast carcinoma than in atypical medullary carcinoma,the expression of E-cadherin and β-catenin was verse relation（P〈0.05）.The expression of E-cadherin andβ-catenin was correlated with lymph node metastasis and clinical stage（P〈0.05）;it was not correlated with age,size of tumor and distant metastasis（P〉0.05）.Conclusion Difference of E-cadherin and β-catenin expression is the important cause of different prognosis in medullary breast carcinoma.