正常乳猪股骨头骨骺的MSCT灌注研究

Study on Blood Perfusion of Normal Femur Heads Epiphyses in Piglets by Multi-Slice CT Perfusion

目的运用多层螺旋CT灌注技术评价正常乳猪股骨头骨骺、骺板软骨、干骺端等不同解剖区域的血液供应特征。方法对15只2周龄的健康乳猪进行多层螺旋CT电影模式灌注扫描,对生成的动态图像数据进行测量分析,共获得26个股骨头的完整图像资料,统计并比较血流量(BF)、血容量(BV)、平均通过时间(MTT)、对比剂到达峰值时间(TTP),并与相应组织学表现进行对照。结果骺板软骨的BF比骨骺的BF有明显增高(P<0.05)。各解剖区域中干骺端的BV最高(P<0.05)、MTT最长(P<0.05),而骺板与骨骺的MTT比较差异无统计学意义(P>0.05)。各解剖区域中骺板软骨的TTP最短(P<0.05),骨骺与干骺端的TTP基本相同。组织学发现骨骺、骺板软骨、干骺端的血管密度分布特征与相应部位的CT增强率所提示的血供状态基本吻合。结论多层螺旋CT灌注能够显示股骨头不同解剖区域的血液灌注特征。

Objective To evaluate the blood perfusion of epiphyses,physis and metaphysis in normal femur heads of piglets by using multi-slice CT perfusion techniques. Methods Fifty five piglets（2 weeks old） were scanned by MSCT perfusion. The data of creating dynamic picture were analyzed, and the dynamic pictures of 26 femur heads were obtained completely. Every parame- ters including blood flow（BF） , blood volume（BV） , mean transit time （MTT） and time to peak （qTP） were analyzed, and compared with the histological findings. Results The BF of physis was higher than that of epiphysis （P 〈 0.05 ）. The BV of metaphysis was the highest in all anatomic regions（ P 〈0.05）. The MTF of epiphysis was the longest（ P 〈0.05 ）. There was no significant difference in MTT between physis and metaphysis （ P 〉 0.05 ）. The TTP of physis was the shortest （ P 〈 0.05 ） , and the other two were the same. CT perfusion imaging coincided with the histological results of the locations and concentrations of blood vessels in epiphyses, physis and metaphysis. Conclusion MSCT perfusion images can demonstrate the perfusion features in the various anatomic regions of femur heads.