风湿性心脏病患者心包液和血液中心钠素与心功能的关系

The corelation between cardiac function and atrial natriuretic peptide levels in pericardial fluid and blood sample in rheumatic heart diseases

目的 探讨心包液和血液中心钠素含量与风湿性心脏病患者心脏功能的关系.方法 风湿性心脏病需行瓣膜置换术患者33例,术中留取心包液和静脉血,利用放射免疫分析方法检测心包液和血浆中心钠素的含量,分析其与心功能的关系.结果 患者心包液中含有高浓度的心钠素,明显高于血浆中的水平[（0.61±0.49）μg/L比（0.45±0.18）μg/L,P=0.046];射血分数＜50%的患者心包液中心钠素的含量明显高于射血分数≥50%的患者[（0.98±0.81）μg/L比（0.48±0.18）μg/L].结论 人心包液中的心钠素可能和血液中的心钠素一样参与心功能的调节.

Objective To investigate the relationship between the cardiac function and the levels of atrial natriuretic peptide （ANP）in pericardial fluid and plasma in patients with rheumatic heart diseases. Methods The study involved 33 patients undergoing open heart surgery for either heart valvuloplasty or valve replacement. ANP concentrations in the plasma, pericardial fluid, and pericardial tissues were measured by using of radioimmunoassay （RIA）. Results The level of ANP in human pericardial fluid was significantly higher than that in the plasma （0.614±0.486 ng/ml vs 0. 451 ±0. 184 ng/ml, P =0. 046）. The ANP concentration in pericardial fluid of patients with left ventricular ejection fraction（LVEF） 〈 50% was much higher than that of patients with LVEF ≥50%. Conclusion The ANP in the pericardial fluid may be involved in the deterioration of cardiac function in patients with rheumatic heart diseases.