国产奈达铂联合氟尿嘧啶治疗晚期食管癌疗效观察

The treatment of advanced esophageal carcinoma with nedaplatin and fluorouracil

目的 观察国产奈达铂＋氟尿嘧啶（5-Fu）方案治疗晚期食管癌的近期疗效和不良反应.方法 将55例食管癌患者,完全随机分为治疗组（28例）和对照组（27例）.治疗组方案：奈达铂,80～100mg/m^2,静脉滴注,d1;5-Fu,750～800 mg/m^2,采用便携式泵持续静脉滴注,d1-5.对照组方案：顺铂,50 mg/m^2,静脉滴注,d1-3;5-Fu的用法同治疗组,每4周重复1次,共4周期.结果 治疗组和对照组的有效率分别为57.7%（15/26）和36.4%（8/22）,差异无统计学意义（P＞0.05）.治疗组各度恶心呕吐的发生率均明显低于对照组（均P＜0.05）;治疗组Ⅰ～Ⅱ度肾脏损害的发生率低于对照组（P＜0.05）.结论 奈达铂＋5-Fu治疗晚期食管癌的疗效不低于顺铂＋5-Fu,且不良反应易于耐受,值得临床推广.

Objective To observe the short term efficacy and side effects of China-made nedaplatin （NDP）and fluorouracil （5-Fu） treating advanced esophageal carcinoma. Methods The therapeutic regimen for NDP group was NDP plus 5-Fu. The therapeutic regimen for control group was Cisplatin plus 5-Fu. Results The efficiency of NDP group was 57.7% （15/26） and the efficiency of the control group was 36.4% （8/22） （P 〉0.05）.The rates of different nausea and vomiting in NDP group were significantly lower than those in control group （ P 〈0.05 ）. The rate of renal toxicity low the control group（ P 〈0.05 ）Diarrhea of two group mostly Appeared Ⅰ-Ⅱ degree; The rate of Ⅰ-Ⅱ degree of leukopenia in the NDP group was higher than that in the control group（ P 〉 0.05 ）.The rate of thrombocytopenia in the NDP group was higher than that in the control group（ P 〉 0.05 ）. Conclusions The efficacy of NDP group is no lower than the control group. NDP group is easily tolerant to the side effect. It can be used widely in clinic.