138例药物性肝损害回顾性调查研究

Retrospective study on 138 cases drug-induced liver injury

目的:探讨药物性肝损害的证候学特点,分析引起药物性肝损害的因素和治疗方法。方法:按照药物性肝损害诊断标准对138例药物性肝损害患者的临床资料进行了回顾性分析,运用证候学将各种药物引起的药物性肝损害进行归类,探讨药物性肝损害的证候规律。药物性肝病的病因在于湿、毒、瘀、虚,病位主要在肝胆脾肾,病性属虚实夹杂,病机关键为湿热阻滞肝胆,临床治疗突出利湿退黄的治疗原则,能够有效治疗药物性肝损害。

Objective： To investigate the syndrome characteristic of drug-induced liver injury,and to analyze the factors of drug-induced liver injury and the methods of treatment.Methods：To analyze retrospectively the clinical materials of 138 cases of drug-induced hepatitis according to the standard of drug-induced liver injury,and to classify those cases Induced by different drugs by theory of syndrome,and to investigate the regularity of TCM Syndrome of drug-induced liver injury.Conclusion： The factors of drug-induced liver injury are dampness-poison,stasis and deficiency.The main location of disease is liver,gallbladder,spleen and kidney.The nature of disease is interminglement with deficiency and excess.The key pathogenesis is dampness-heat blocking in liver and gallbladder.The main therapeutic principles of removing dampness and eliminating jaundice have the effficiency on the treatment of drug-induced liver injury.