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13^2-羟基脱镁叶绿酸-a甲酯的合成及其立体结构的表征与确定 被引量：5

Synthesis of Methyl 13^2-Hydroxylpheophorbide-a and Characterization and Identification of Their Stereostructure
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摘要 以叶绿素-a为起始原料,经过酯交换和去除金属离子得到焦脱镁叶绿酸-a甲酯,在热乙酸中的空气氧化得到132(R/S)-132-羟基脱镁叶绿酸-a甲酯的混合物,在氢氧化钾甲醇溶液中的空气氧化主要给出作为氧化和重排产物的红紫素-18甲酯.通过层析将非对映体相互分离,对其核磁共振氢谱进行讨论并对立体结构进行表征和确定. Chlorophyll-a is used as starting material and comnverted into methyl pyropheophorbide-a by transesterification and removement of metal ion.13^2（R/S）-132-hydroxylpheophorbide-a as a mixture is obtained by allomerization in heat acetic acid.The purpurin-18 methyl ester as a major oxidized and rearranged product is produced by air-oxidation in methanolic potassium hydroxide.The diastereoisomers are separated by column chromatography and stereostructures are characterized and identified by 1H NMR spectra.
作者 张千 姚楠楠 武进 王进军
机构地区 烟台大学化学生物理工学院 烟台大学药学院
出处 《烟台大学学报（自然科学与工程版）》 CAS 北大核心 2011年第1期27-33,共7页 Journal of Yantai University(Natural Science and Engineering Edition)
基金 山东省自然科学基金资助项目(Y2008B49)
关键词 叶绿素-A 二氢卟吩 脱镁叶绿酸-a甲酯 立体化学 表征 chlorophyll-a chlorin methyl pheophorbidel-a stereochemistry characterization
分类号 O62 [理学—有机化学]
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参考文献8

二级参考文献21

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共引文献59

同被引文献35

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引证文献5

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烟台大学学报（自然科学与工程版）
2011年 第1期

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