慢性肾衰竭患者止凝血功能的变化

Changes of hemostatic and coagulative functions in patients with chronic renal failure

目的探讨止血、凝血系统的变化与慢性肾衰竭并发出血的关系。方法检测55例慢性肾衰竭患者血小板聚集率(PAgT)、P-选择素、血管性血友病因子∶抗原(vWF∶Ag)含量;凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、抗凝血酶Ⅲ(AT-Ⅲ)活性、血浆蛋白C(PC)活性,并与40例健康者比较。结果慢性肾衰竭患者PAgT、P-选择素、AT-Ⅲ活性、血浆PC明显降低,与对照组比较,差异有统计学意义(P<0.01);vWF∶Ag含量升高,与对照组比较,差异有统计学意义(P<0.01),PT、APTT与对照组比较,差异无统计学意义(P>0.05)。结论慢性肾衰竭患者存在出血和血栓栓塞两种状态。

Objective To explore the relationship between chances of hemostatic and coagulative functions with chronic renal failure（CRF） complicating hemorrhage. Methods The level of platelet aggregation rate（PAgT）, P-selectin,von Willebrand factor Ag（vWF ： Ag）, prothrombin time（PT）, activated partial thromboplastin time （APTT） ,anti-thrombin Ⅲ （AT-Ⅲ）and protein C（pC） were detected in 56 patients. The results were compared with those in 40 healthy subjects. Results PagT, P selectin, AT-Ⅲ, PC in CRF patienls were significantly lower than those in the control group with statistical significance （P〈0.01）. The levels of vWF ： Ag in the patients were higher than those in the control with statistical significance（P〈0.01 ）. The levels of PT and APTT had no statistical difference compared with the control（P〉0. 05）Conclusion The status of hemorrhage and thrombus exists in the patients with CRE.