手足口病患儿治疗前后超敏C反应蛋白和肌酸激酶同工酶的变化及临床意义

Clinical significance and changes of hs-CRP,CK-MB in HFMD children before and after treatment

目的观察手足口病患儿治疗前后超敏C反应蛋白(hs-CRP)的变化并探讨其临床意义。方法分别检测30例健康儿童、89例手足口病患儿治疗前和治疗7d后hs-CRP和肌酸激酶同工酶(CK-MB)水平。结果手足口病患儿组与健康对照组比较,治疗前hs-CRP和CK-MB升高差异有统计学意义(P<0.01)。经综合治疗7d后hs-CRP下降明显,与治疗前比较差异有统计学意义(P<0.01),而CK-MB变化无统计学意义。结论 hs-CRP是手足口病敏感而非特异的早期诊断指标,治疗前后检测对比可指导临床疗效判断。

Objective To observe the clinical significance and changes of hs-CRP,CK-MB in children infected with hand,foot and mouse disease（HFMD） before and after treatment. Methods 30 cases of healthy children and 89 cases of HFMD children were detected separately CK-MB and hs-CRP level before and after 7 d treatment. Results Before treatment,compared with the healthy control group,the level of hs CRP and CK-MB in HFMD children were significantly increased（P〈0.01）. After 7 d combined treatment,hs CRP content change of HFMD children was significantly lower than before（P〈0.01 ）, hut CK-MB content change of HFMD children had no statistical significance. Conclusion hs-CRP is an early, sensitive but non-specific indicator of diagnosing HFMD, which can guide clinical therapy judgment before and after treatment.