转移因子联合抗痨药物治疗老年肺结核的疗效观察

Curative effect of transfer factor capsules and antituberculosis drugs on senile lung tuberculosis

目的观察和评价转移因子胶囊联合抗痨药物治疗老年肺结核的疗效。方法将210例老年肺结核病人随机分为治疗组和对照组各105例,对照组采用2HRZE/4HR方案治疗,治疗组采用上述方案治疗的同时加用转移因子胶囊口服观察痰菌阴转、肺部病灶吸收、空洞闭合等情况。结果 1个月后治疗组痰菌阴转82例(78.1%),对照组57例(54.3%);2个月后治疗组95例(90.5%),对照组78例(74.3%);两组比较差异均有统计学意义(P<0.01);3个月后治疗组104例(99.0%),对照组101例(96.2%),两组比较差异无统计学意义(P>0.05)。病变吸收在2、4、6个月显著有效及有效病例:治疗组分别为41、76、102例,对照组分别为22、57、79例,两组比较差异有统计学意义(P<0.01)。空洞闭合在2、4、6个月显著有效及有效病例:治疗组分别为20、33、38例,对照组分别为11、25、31例,两组比较差异有统计学意义(P<0.05)。结论转移因子胶囊联合抗痨药物治疗老年肺结核有显著疗效。

Objective To observe and assess the curative effect of transfer factor capsules and antituberculosis drugs on senile lung tuberculosis. Methods 210 patients were divided into two groups, namely the case group and the control group. The control group was treated with 2HRES/4HR. The case group was treated with 2HRES/4HR combined with oral transfer factor capsules. The sputum negative conversion, focus absorption and cavity closure were observed. Results There were 82 cases in the cases group and 57cases in the control group with sputum negative conversion 1 month after treatment and the difference was significant （P〈0.01 ）. There were 95 cases in the cases group and 78 cases in the control group with sputum negative conversion 2 month after treatment after and the difference was also significant （P〈0.01）. There were 41,76 and 102 cases in the cases group and 22,57 and 79 cases in the control group 2 months,4 months and 6 months after treatment （P〈0.01）. There were 20,33 and 38 cases in the cases group and 11,25 and 31 cases in the control group 2 months, 4 months and 6 months after treatment and the difference was significant （P〈0.05 ）. Conclusions The curative effect of transfer factor capsules and antituberculosis drugs on senile lung tuberculosis cured by is obvious.