小剂量氨茶碱联合肺康复治疗老年慢性阻塞性肺疾病患者的疗效观察

Effect of low-dose theophyline combined with pulmonary rehabilitation in elderly patients with chronic obstructive pulmonary disease

目的观察小剂量氨茶碱联合肺康复治疗老年慢性阻塞性肺疾病(Chronic obstructive pulmonary dis-ease,COPD)稳定期患者的疗效。方法老年COPD稳定期患者随机分成试验组和对照组各20例,实验组患者口服氨茶碱片(100 mg,2次/日)同时进行肺康复治疗,对照组仅口服同样剂量氨茶碱片。观察治疗6个月后患者呼吸困难症状(MRC评分)、日常生活活动能力(ADL评分)和肺功能的变化。结果两组患者在治疗后MRC评分降低,ADL评分提高,差异均有统计学意义(P<0.05)。治疗后实验组MRC评分及ADL评分较对照组改善更明显,差异有统计学意义(P<0.05);两组患者治疗后肺功能指标改变无统计学意义。结论小剂量氨茶碱联合肺康复治疗,可进一步减轻老年COPD稳定期患者呼吸困难症状,增强日常生活活动能力,提高生活质量,值得临床推广。

Objective To study the effect of low-dose oral theophyline combination with pulmonary renamnranon in elderly patients with stable chronic obstructive pulmonary disease. Methods 40 patients were divided into two groups by randomized control trial. Patients in the experimental group received theophyline and pulmonary rehabilitation. Patients in control group received theophyline only. Breathlessness, activities of daily living, and lung function were measured six months after treatment. Results After experiment, Medical research council scale grade was lower and the activities of daily living were increased （P〈0. 05 ）, but the pulmonary function measurements were not improved significantly. There were significant improvements in MRC and ADL in experimental group. Conclusion In elderly patients with stable chronic obstructive pulmonary disease, low-dose oral theophyline combined with pulmonary rehabilitation can ameliorate dyspnea and improve activities of daily living.