氨氯地平对高原地区高血压患者的降压效果观察

Effect of amlodipine besylate on hypertension in a high-altitude population

【目的】了解西藏地区藏汉高血压患者的特点及氨氯地平在高原地区的降压效果。【方法】选取2009年4月-2009年10月于武警西藏总队医院就诊的56例世居藏族高血压患者(藏族组)和50例移居汉族高血压患者(汉族组)。记录一般情况,各项化验结果,登记基础血压和心率。给予氨氯地平5 mg/d治疗8周,分别于治疗后4周和8周复测两组患者的血压和心率。【结果】汉族患者中高血压家族史较少,两组患者的其他一般情况无明显差异。汉族组舒张压基础值比藏族组高[,(99.7±6.2)mmHg VS(94.2±9.1)mmHg,P<0.05],基础收缩压和心率两组无明显差异。治疗4周后两组收缩压均有明显下降,藏族组(146.3±3.4)mmHg VS(141.2±4.6)mmHg,P<0.05]和汉族组[(143.2±4.1)mmHg VS(138.7±6.3)mmHg,P<0.05]。治疗8周舒张压两组均有下降,藏族组[(94.2±9.1)mmHg VS(89.2±6.3)mmHg,P<0.05]和汉族组[(99.7±6.2)mmHg VS(93.3±5.8)mmHg,P<0.05],汉族高血压患者舒张压仍未达标。【结论】高原地区高血压患者舒张压升高较明显,氨氯地平降低收缩压效果明显,降低舒张压效果尚不理想。

【Objective】To investigate the character of hypertension in high-altitude population and the effect of amlodipine on lowering blood pressure in a Tibetan population.【Methods】 A total 106 patients from April to October in 2009 were enrolled in the trial and divided into 2 groups（Han group n=50;Tibetan group n=56） according to their race,their blood presure were measured.They were treated with amlodipine（5 mg/d） for 8 weeks.The blood pressure were measured again at the 4th and 8th week.【Results】The basic diastolic BP of Han group was a little higher than Tibetan group [（99.7±6.2） mmHg VS（94.2±9.1） mmHg,P0.05].At 4th week,the systolic BP was decreased significangtly Tibetan [（146.3±3.4） mmHg VS（141.2±4.6） mmHg,P0.05];Han [（143.2±4.1） mmHg VS（138.7±6.3） mmHg,P0.05].At 8th week,the diastolic BP was decreased significantly Tibetan [（94.2±9.1）mmHg VS（89.2±6.3） mmHg,P0.05];Han [（99.7±6.2） mmHg VS（93.3±5.8）] mmHg,P0.05].The diastolic BP of Han group was above normal limit.【Conclusion】 In a high altitude population,the diastolic BP was increased more often,and routine amlodipine is effective on lowering systolic BP.