摘要
Seven compounds (1–7) were identified from the cultivation of the endophytic fungus Exophiala oligosperma (EN-21) that was isolated from the inner tissue of the marine red alga Laurencia similis. Their structures were identified with spectroscopic and chemical methods as 2-phenoxynaphthalene (1), (2S, 3R, 4E, 8E)-1-O-β-D-glucopyranosyl-3-hydroxy-2-[(R)-2′-hydroxyoctadecanoyl] amino-9-methyl-4, 8-octadeca-diene (2), (22E,24R)-ergosta-7,22-dien-3β,5α,6β-triol (3), (22E, 24R)-3β, 5α, 9α-trihydroxy- ergosta-7, 22-dien-6-one (4), (22E, 24R)-5α, 6α-epoxy-ergosta-8, 22-dien-3β, 7α-diol (5), (22E, 24R)- ergosta-4, 6, 8(14), 22-tetraen-3-one (6), and euphorbol (7). This paper reports for the first time the chemical constituents of fungus Exophiala oligosperma and the discovery of compound 1 as a natural product from the fungus.
Seven compounds （1 7） were identified from the cultivation of the endophytic fungus Exophiala oligosperma （EN-21） that was isolated from the inner tissue of the marine red alga Laurencia similis. Their structures were identified with spectroscopic and chemical methods as 2-phenoxynaphthalene （1）, （2S, 3R, 4E, 8E）-1-O-β-D-glucopyranosyl-3-hydroxy-2-[（R）-2＇-hydroxyoctadecanoyl] amino-9-methyl-4, 8-octadeca-diene （2）, （22E,24R）-ergosta-7,22-dien-3β,5α,6β-triol （3）, （22E, 24R）-3β, 5α, 9α-trihydroxy- ergosta-7, 22-dien-6-one （4）, （22E, 24R）-5α, 6α-epoxy-ergosta-8, 22-dien-3β, 7α-diol （5）, （22E, 24R）- ergosta-4, 6, 8（14）, 22-tetraen-3-one （6）, and euphorbol （7）. This paper reports for the first time the chemical constituents of fungus Exophiala oligosperma and the discovery of compound 1 as a natural product from the fungus.
基金
Supported by the Programs from the Ministry of Science and Technology of China (Nos.2007AA09Z446,2010CB833802)
the Knowledge Innovation Program of Chinese Academy of Sciences (KZCX2-YW-211-04)
