2例肌苷葡萄糖注射液配药后不明絮状物的红外光谱分析

Infrared Spectrum Analysis of the Unknown Floss of in Inosine Glucose Injection

目的:分析临床配药过程中出现的2例与肌苷葡萄糖注射液有关的絮状物的成分。方法:将临床配药过程中肌苷葡萄糖注射液与阿昔洛韦注射液混合及肌苷葡萄糖注射液与还原型谷胱甘肽混合时出现的不明絮状物分离出,低温干燥后进行红外光谱扫描,扫描结果通过与SDBS(Spectral Data Base System)谱图数据库中各组分红外图谱峰位、峰形及相对强度进行对比,确定是否为单一物质,分析原因。结果:该絮状物既不是肌苷,也不是阿昔洛韦或还原型谷胱甘肽,为菌类污染的可能性极大。结论:对于肌苷葡萄糖注射液类生物药品,临床使用时应先仔细观察外观后再行配药。

OBJECTIVE：To analyze the unknown floss of Inosine glucose injection in 2 cases during drug dispensing.METHODS：The unknown floss was isolated from mixture of Inosine glucose injection with Acyclovir injection and mixture of Inosine glucose injection with reduced glutathione.Isolated unknown floss was analyzed by infrared spectroscopy（IR）after cold drying.Results of IR were compared with SDBS（Spectral Data Base System）in terms of IR peak,peak shape and relative peak density to confirm whether the unknown floss was homogenous material or not and analyze its reason.RESULTS：The floss was not inosine or reduced glutathione or acyclovir.It was most likely a kind of bacteria.CONCLUSION：For such biological drugs of Inosine glucose injection,appearance should be observed carefully before clinical utilization.