摘要
目的观察支扩稳定方治疗稳定期支气管扩张症的临床疗效。方法将84例患者随机分为对照组和对照组各42例,对照组予西医常规治疗,治疗组在西医常规治疗基础上给予中药支扩稳定方。两组均以3个月为1个疗程,共治疗2个疗程;观察治疗前后两组患者急性发作次数、圣乔治生活质量评分、中医证候评分、24 h痰量等的变化情况。结果治疗组脱落1例,对照组脱落3例。治疗后治疗组急性发作频率低于对照组(P<0.05);治疗组治疗后圣乔治总评分明显降低(P<0.05),且治疗组总分变化率与对照组差异有统计学意义(P<0.05);治疗组治疗后咳嗽、咳痰、喘息、乏力、纳呆等中医证候积分及总积分均低于对照组(P<0.05),24 h痰量亦少于对照组(P<0.05)。结论中药支扩稳定方辨证施治联合西医常规疗法,能改善支扩稳定期患者的临床症状,提高患者生活质量,减少半年内急性发作次数,减少痰量,且安全性良好,值得进一步研究。
Objective To evaluate the effects of "Stable Bronchiectasis Prescription"combined with western medicine on stable bronchiectasis. Methods Eighty-four cases of stable bronchiectasis were randomly divided into control group and TCM group.The control group was treated with conventional therapy,while the TCM group was treated with conventional western therapy together with "Stable Bronchiectasis Recipe"modified by syndrome differentiation for three months.After six months,the frequency of acute exacerbations,scores of St George's respiratory questionnaire(SGRQ),scores of TCM syndromes and amount of sputum in 24 hours were determined. Results One case in the TCM group and three cases in the control group dropped out.The frequency of acute exacerbations of the TCM group decreased significantly than the control group(P0.01).The scores of St George's respiratory questionnaire of the TCM group improved significantly(35.90 ± 18.81 vs 41.27 ± 18.04,P0.01),the variance ratio of SGRQ of the TCM group was better than that of the control group(-13.60% ± 18.60% vs-2.86% ± 21.02%,P0.05).The improvement of TCM syndromes scores of the TCM group was more significant than the control group(P0.01),in which cough,expectoration,dyspnea,lacking in strength and anorexia improved significantly(P0.05),the sputum in 24 hours of the TCM group decreased significantly(P 0.05).Conclusion "Stable Bronchiectasis Recipe" may improve the symptoms,enhance the quality of life,reduce the frequency of acute exacerbations and amount of sputum of patients with stable bronchiectasis,and shows good safety.So it is worthy of further study.
出处
《上海中医药杂志》
2011年第1期33-36,共4页
Shanghai Journal of Traditional Chinese Medicine
关键词
支气管扩张症
稳定期
中医药疗法
扶正化痰清热法
生活质量
bronchiectasis
stable stage
Chinese medicine
therapeutic method of strengthening body resistance
reducing phlegm and clearing heat
quality of life