期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

青藤碱治疗类风湿性关节炎抑制骨破坏的研究进展 被引量：12

Study on Sinomenine in Treating Rheumatoid Arthritis and Inhibiting Osteoclasia
下载PDF
导出
摘要 类风湿性关节炎(rheumatoid arthritis,RA)骨质侵蚀与关节破坏是近年来研究的热点。破骨细胞是导致关节侵蚀的主要细胞。将近几年青藤碱(sinomenine,SIN)在类风湿性关节炎骨破坏的调控机制予以综述,以期进一步研究SIN对RA破骨细胞的作用机制。 Osseous erosion and articular destruction in rheumatoid arthritis（RA） have become research hotspots in recent years.Osteoclasts are main cells resulting in articular erosion.The regulatory mechanism of sinomenine（SIN） in rheumatoid arthritis osteoclasia in recent years is researched in the paper to further study the mechanism of SIN on RA osteoclasts.
作者 丁从珠 汪悦 姚瑶 方芸 赵成 冯学兵 孙凌云
机构地区 南京中医药大学中西医结合鼓楼临床医学院 南京中医药大学第一临床医学院
出处 《南京中医药大学学报》 CAS CSCD 北大核心 2011年第1期98-100,共3页 Journal of Nanjing University of Traditional Chinese Medicine
基金 江苏省六大人才高峰基金(2010WSW-008) 南京市医学科技发展重点项目(ZKX08022)
关键词 类风湿性关节炎 青藤碱 骨破坏 rheumatoid arthritis sinomenine osteoclasia
分类号 R285 [医药卫生—中药学]
  • 相关文献

参考文献22

  • 1Li P, Schwarz EM, O'Keefe RJ, et al. RANK signaling is not required for TNFalpha-mediated increase in CD11 (hi) osteoclast precursors but is essential for mature osteoclast formation in TNFalpha-mediated inflammatory ar thritis[J]. J Bone Miner Res, 2004 ; 19(2) : 207 - 213.
  • 2Redlich K, Hayer S, Ricci R, et al. Osteoclasts are essential for TNF-amediated joint destruction[J]. J Clin Invest, 2002,110: 1419 - 1427.
  • 3金晓琨,李卫东,滕慧玲,林志彬.青藤碱对核转录因子κB及其抑制因子IκB的影响[J].中国药理学通报,2004,20(7):788-791. 被引量：22
  • 4王勇,方勇飞,周新,钟兵,罗中华.青藤碱对佐剂性关节炎大鼠腹腔巨噬细胞表达细胞因子的影响[J].中华风湿病学杂志,2003,7(7):415-419. 被引量：35
  • 5Horwood NJ, Kartsogiannis V, Quinn JM, et al. Activated T lymphocytes support osteoclast formation in vitro [J]. Biochem Biophys Res Commun, 1999,265 : 144 - 150.
  • 6Takayanagi H, Ogasawara K, Hida S, et al. T-cell-mediated regulation of osteoclastogenesis by signalling cross talk between RANKL and IFN-7[J]. Nature, 2000,408: 600 - 605.
  • 7Sato K, Suematsu A, Okamoto K, et al. Thl 7 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction[J]. J Exp Med, 2006,203 : 2673 - 2682.
  • 8Kotake S, Udagawa N, Takahashi N, et al. IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis[J]. J Clin Invest, 1999,103 :1345 - 1352.
  • 9Acosta-Rodriguez EV, Napolitani G, Lanzavecchia A, et al. Interleukins 113 and 6 but not transforming growth factor-1β are essential for the differentiation of interleukin 17-producing human T helper cells[J]. Nat Immunol, 2007,8:942 - 949.
  • 10李晓娟,王培训,刘良,陈光星,肇静娴,曾耀英,陈纪藩.青藤碱对T淋巴细胞活化及TH1类细胞内细胞因子表达的影响[J].中国免疫学杂志,2004,20(4):249-252. 被引量：23

二级参考文献62

  • 1佘建强,黄宇明.正清风痛宁治疗风湿病695例临床总结[J].湖南中医杂志,1994,10(2):18-20. 被引量：18
  • 2Kim KY,Kim MY, Choi HS, et al. Thrombin induces IL-10 production in microglia as a negative feedback regulator of TNF-alpha release. Neuroreport ,2002,13: 849-852.
  • 3Niki Y, Yamada H, Seki S, et al. Macrophage and neutrophil dominant arthritis in human IL-1 alpha transgenic mice. J Clin Invest,2001,107:1127-1135.
  • 4Ma W, Lim W, Gee K, et al. The p38 mitogen activated kinase pathway regulates the human interleukin-10 promoter via the activation of Sp1 transcription factor in lipopolysaccharide stimulated human macrophages. J Biol Chem, 2001,276 : 13664-13674.
  • 5Dayer J M. The process of identifying and understanding cytokines:from basic studies to treating rheumatic diseases [ J ]. Best Pract Res Clin Rheumatol, 2004, 18(1): 31-45.
  • 6Kanda A, Ebihara S, Takahashi H, et al. Loxoprofen sodium suppresses mouse tumor growth by inhibiting vascular endothelial growth factor[J]. Acta Oncol, 2003, 42(1): 62-70.
  • 7Voulgari P V, Kolios G, Papadopoulos G K, et al. Role of cytokines in the pathogenesis of anemia of chronic disease in rheumatoid arthritis[J]. Clin Immunol, 1999, 92(2): 153-160.
  • 8Kroot E J, de Jong B A, van Leeuwen M A, et al. The prognostic value of anti-cyclic citrullinated peptide antibody in patients with recentonset rheumatoid arthritis [ J ]. Arthritis Rheum, 2000, 43 ( 8 ): 1831- 1 835.
  • 9Berg L, Lampa J, Rogberg S. Increased peripheral T-cell reactivity to microbial antigens and collagen type II in rheumatoid arthritis after treatment with soluble TNF-α receptors [J]. Ann Rheum Dis, 2001,60(2):133-139.
  • 10Weyand CM, Goronzy JJ, Takemura S. Interactions between T cells and B cells in rheumatoid arthritis [J]. Arthritis Res, 2000,2:457-463.

共引文献163

同被引文献223

引证文献12

二级引证文献79

南京中医药大学学报
2011年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部