胃癌肿瘤标志物及临床意义

Tumor marker for gastric cancer and its clinical significance

胃癌肿瘤标记物检测样本包括血清,腹水、胃液、组织等,其中血清标志物临床应用较为普遍,主要有CEA、CA72-4、CA50、CA19-9、CA242、MG-Ag及VEGF。胃液中包括传统肿瘤标记物CA72-4、CEA、CA19-9、CA242等及新近研究发现的α1抗-胰蛋白酶及M INT25甲基化的检测。腹水肿瘤标志物主要有ACEA、RegIV,其分别对判断胃癌预后及腹膜早期转移有一定的意义。胃癌组织肿瘤标志物p53基因、细胞周期相关抗原(K i-67)、表皮生长因子受体(ep iderm al growth factor recep-tor,EGFR)、金属蛋白酶(m etalloprofe inases,MMPs)及其抑制剂(tissue inh ib itors of m etalloprote inases,TIMPs)、环氧合酶-2(cy-c looxygenase-2,COX-2)及CD133的检测对于判断预后有一定的价值。采用多种标志物联合检测,或不同检测方法联合检测,有利于提高胃癌的早期诊断率。

The test samples of tumor markers for gastric cancer include blood serum, ascites, gastric juice, gastric tissues and so on. Serum tumor markers mainly include CEA,CA72-4, CA50,CA19-9, CA242, MG-Ag and VEGF. Traditional tumor markers in gastric juice include CA72-4, CEA, CA19-9, CA242 etc. Besides,the newly found alphal-antitrypsin in recent studies and the methylation of MINT25 were tested. ACEA and RegIV are the tumor markers of ascites,which can predict the prognosis and early matastasis of peritoneum respectively. Tumor markers for gastric cancer which exist in gastric tissues can predict the prognosis to a certain degree. These markers include p53 gene, cell cycle related antigen （ Ki-67 ） , epidermal growth factor receptor, metalloproteases and their inhibitor,cyelooxygenase-2 and CD133. It will be helpful to improve the early diagnosis if we combine some tumor markers or different test methods.