匹维溴胺联合谷维素治疗肠易激综合征的临床疗效观察

Clinical observation of pinaverium bromide combined oryzanol in treatment of irritable bowel syndrome

目的:观察匹维溴胺、谷维素联合治疗肠易激综合征的临床治疗效果。方法:将58例肠易激综合征患者随机分为观察组30例和对照组28例。对照组给予匹维溴胺治疗,1d3次,每次50mg。观察组在对照组治疗基础上另给予谷维素治疗,1d3次,每次30mg。以30d为1个疗程,观察两组的临床治疗效果。结果:观察组30例中总有效例数为29例,占96.67%,对照组28例中总有效例数为20例,占71.43%。两组总有效率比较,差异有统计学意义(χ2=5.24,P<0.05)。观察组显效率(56.67%)与对照组相比,差异有统计学意义(χ2=5.99,P<0.05)。所有患者均未见明显不良反应。结论:对肠易激综合征患者应用匹维溴胺、谷维素联合治疗,疗效显著,复发少,值得临床推广应用。

Objective：To observe the clinical efficacy of pinaverium bromide and oryzanol in the treatment of irritable bowel syndrome.Methods：58 patients with irritable bowel syndrome were randomly divided into observation group of 30 patients,28 patients in control group.Control group were given pinaverium bromide treatment,three times a day,each 50 mg.Observation group were treated on the basis of another given oryzanol treatment three times a day,each 30 mg.30-day cycle,observed the clinical effect.Results：30 patients observed total number of valid cases 29 cases,accounting for 96.67%,control group 28 patients,the total number of valid cases 20 cases,accounting for 71.43%.The total effective rate was significant difference（χ2=5.24,P0.05）.Observed significant efficiency（56.67%） compared with the control group,differences were statistically significant（χ2=5.99,P0.05）.And all patients had no obvious adverse reactions.Conclusion：Pinaverium bromide and oryzanol combination therapy is significantly effect,relapse,which should be clinical application.