大剂量盐酸氨溴索对ARDS患者呼吸功能的影响

Effect of high dose ambroxol on the pulmonary function of patients with ARDS

目的:研究大剂量盐酸氨溴索对急性呼吸窘迫综合征(ARDS)患者呼吸功能的影响。方法:选择ARDS患者60例,随机分成小剂量盐酸氨溴索组(A组,n=20),大剂量盐酸氨溴索组(B组,n=20),对照组(C组,n=20)。A组每天给予盐酸氨溴索2mg/kg加0.9%氯化钠溶液500ml静脉滴注,B组每天给予盐酸氨溴索15mg/kg加0.9%氯化钠溶液500ml静脉滴注,C组每天给予0.9%氯化钠溶液500ml静脉滴注,连续使用7d。比较各组患者用药前,用药第3、7天动脉血氧分压(PaO2)、动脉血氧饱和度(SaO2)、氧合指数(PaO2/FiO2)的差异。结果:用药前各组间PaO2、SaO2和PaO2/FiO2无差异。用药第3、7天PaO2、SaO2及PaO2/FiO2,A、B组与C组比较,差异有统计学意义(P<0.05),A组与B组比较,差异有统计学意义(P<0.05)。结论:盐酸氨溴索对ARDS患者呼吸功能有改善作用,且大剂量盐酸氨溴索对ARDS患者呼吸功能的改善作用强于小剂量盐酸氨溴索。

Objective：To investigate the effect of high dose ambroxol on the lung function of patients with acute respiratory distresssyndrome（ARDS）.Methods：60 patients with ARDS were enrolled in the study.They were divided randomly into 3 groups.Patients in group A were treated with low dose ambroxol（2 mg/kg）＋0.9%NaCl（500 ml）,patients in group B received high dose ambroxol（15 mg/kg）＋0.9%NaCl（500 ml）,others in group C were treated with 0.9%NaCl（500 ml） alone,for 7 consecutive days.The arterial blood samples were taken for blood gas and the parameters of respiratory mechanics were recorded before ambroxol infusion.Outcome of patients in both groups including various pulmonary function indices was analyzed.Results：The blood gas indexes of the patients in group A and group B were better than group C（P0.05）,the blood gas indexes of the patients in group B were better than group A（P0.05）.Conclusion：Ambroxol can enhance the pulmonary function in patients with ARDS.The effect of high dose ambroxol on the lung function of patients with ARDS is better than low dose.