Meta分析p53基因第72位密码子多态性和结直肠癌的发病风险的关系

Meta analysis the relationship between p53 gene codon 72 polymorphim and risk of colorectal cancer development

目的:Meta分析p53基因第72位密码子多态性和结直肠癌发病易感性的关系。方法:从Medline,Embase和CNKI数据库中检索研究p53基因第72位密码子多态性与和结直肠癌易感性关系的公开发表论文,使用Stata软件合成分析p53各基因型与结直肠癌易感性的关系。使用比值比(Odds Ratio,OR)和95%可信区间(95%Confidence Interval,95%CI)作为效应指标。同时评价所纳入研究的异质性及发表偏移。结果:共有12篇关于p53基因第72位密码子多态性和结直肠癌易感性的公开发表论文被纳入本研究。12篇纳入文献中总共包括病例2459例,对照3632例。合成分析发现p53基因第72位密码子的Arg等位基因、ArgPro基因型和Pro等位基因分布的比值比(OR)和95%可信区间(95%CI)分别为[1.03;0.89～1.18],[0.98;0.89～1.08]和[1.10;0.94～1.31]。以研究人群进行亚组分层分析发现亚洲人中p53基因的Arg等位基因、ArgPro基因型和Pro等位基因分布的OR和95%CI分别为[0.90;0.68～1.19],[1.04;0.90～1.21]和[1.20;0.82～1.77];在高加索人中p53基因的Arg等位基因、ArgPro基因型和Pro等位基因分布的OR和95%CI分别为[1.07;0.95～1.20],[0.94;0.83～1.07]和[0.91;0.70～1.17]。通过Begger和Egger方法检测均未发现存在发表偏移。结论:本研究提示p53基因第72位密码子多态性与结直肠癌的发病率无直接关系,p53基因多态性可能不是结直肠癌易感性的独立影响因素。

Objective：Meta analysis the relationship between p53 gene codon 72 polymorphim and risk of colorectal cancer development.Methods：Databases of Medline,Embase and CNKI were computerizedly searched.Odds ratio（OR） and 95% confidence interval（95%CI） were used to evaluate the strength of association between p53 gene codon 72 polymorphim and risk of colorectal cancer development.At the same time,heterogeneity between included studies and publication bias were also evaluated.Results：Total twelves case-control studies with 2459 cases of colorectal cancer and 3632 controls were included into this study.Combined analysis revealled that ORs and 95%CIs for genotypes of ArgArg,ArgPro and ProPro genotypes were [0.90;0.68-1.19],[1.04;0.90-1.21]和[1.20;0.82-1.77].Stratified analysis according different ethnics revealled that ORs and 95%CIs for genotypes of ArgArg,ArgPro and ProPro among Asians were [0.90;0.68-1.19],[1.04;0.90-1.21]和[1.20;0.82-1.77] and among Caucasians were [1.07;0.95-1.20],[0.94;0.83-1.07]和[0.91;0.70-1.17].Conclusion：This meta analysis suggested that there were no evident association between p53 gene codon 72 polymorphims and risk of colorectal cancer development.Individual with p53 gene codon 72 polymorphims did not at risk of colorectal cancer development.