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评述氯喹的作用机制假说 被引量:9

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摘要 早期临床实践发现,氯喹、奎纳克林、金鸡纳生物碱的抗疟作用只限于疟原虫生活史中能降解血红蛋白的阶段。红内期疟原虫对氯喹的敏感性与其血红蛋白的分解代谢程度一致。感染疟原虫的红细胞内,氯喹积聚的浓度远远超过未感染的红细胞内氯喹的浓度。Sinden等[1]报...
出处 《中国人兽共患病杂志》 CSCD 北大核心 1999年第4期101-103,共3页 Chinese Journal of Zoonoses
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参考文献3

  • 1Song G H,Proc Soc Exp Biol Med,1994年,205卷,2期,198页
  • 2Zhang Y,Biochem Pharmacol,1987年,64卷,322页
  • 3Chou A C,Biochemistry,1980年,19卷,1543页

同被引文献65

  • 1鲁建华,俸军林.癫痫脑损伤及脑保护的研究进展[J].山东医药,2009,49(52):108-109. 被引量:7
  • 2张树华,朱长庚,刘庆莹,王伟.Effects of Chloroquine on GFAP, PCNA and Cyclin D1 in Hippocampus and Cerebral Cortex of Rats with Seizures Induced by Pentylenetetrazole[J].Journal of Huazhong University of Science and Technology(Medical Sciences),2005,25(6):625-628. 被引量:6
  • 3Eddleston M, Mucke L. Molecular profile of reactive astrocytes implications for their role in neurologic disease [J]. Neuroscience,1993, 54(1): 15.
  • 4Romcy-Pereira RN, Garcia-Cairasco N. Hippocample cell proliferation and epileptogenesis after audiogenic kinding are not accompanied by mossy fiber sprouting or Fluoro-Jade staining [J]. Neuroscience,2003, 119(2): 533.
  • 5Stringer JL. Repeated seizures increased GFAP and Vimentin in hippocampus[J]. Brain Res, 1996, 717(1): 147.
  • 6Imai H, Harland J, McCulloch J, et al. Specific expression of the cell cycle regulation proteins, GADD34 and PCNA in the peri-infarct zone after focal cerebrial ischemia in the rat[J]. Eur J Neurosci, 2002,15(6): 1929.
  • 7Johnson DG, Walker CL. Cyclins and cell cyclecheckpoints[J]. Annu Rev Pharmacol Toxicol, 1999, 39(2): 295.
  • 8Savarino A, Boelaert JR, Cassone A, et al, Effects of chloroquine on viral infections: an old drug against today's diseases? [J]. Lancet Infections Diseases, 2003, 3(11): 722-727.
  • 9Diehl RG, Smialowski A, Gotwo T. Development and persistence of kindled seizures after repeated injection of pentylenetetrazole in rats and Guinea pigs[J]. Epilepsia, 1984, 25(4): 506.
  • 10Legssyer K, Josse C, Piette J, et al. Changes in function of iron-loaded alveolar macrophages after in vivo administration of desferrioxamine and/or chloroquine[J]. J Inorg Biochem, 2003, 94(1): 36.

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