支气管冲洗液与血清CA-50测定对肺癌诊断的价值

Evaluation of CA-50 assay in bronchial washings fluid and serum for diagnosis of lung cancer

目的 探讨支气管冲洗液与血清CA - 5 0测定对肺癌的诊断价值。方法 用放射免疫法检测 4 9例肺癌和 5 9例良性肺部疾病患者支气管冲洗液与血清CA - 5 0水平。结果 肺癌组支气管冲洗液CA - 5 0值显著高于良性肺部疾病组 (P <0 0 5 ) ,肺癌血清CA - 5 0值亦显著高于良性肺部疾病血清CA - 5 0值 (P <0 0 5 )。肺癌组支气管冲洗液与血清CA - 5 0值比较差异有显著性 (P <0 0 0 1) ,良性肺部疾病组支气管冲洗液与血清CA - 5 0值比较差异亦有显著性 (P <0 0 0 1)。结论 同时测定支气管冲洗液与血清CA - 5 0 ,若二者均升高有助于肺癌的诊断。CA - 5 0测定对肺癌的病情监测亦可能有一定意义。

Objective To investigate the evaluation of CA-50 assay in bronchial washings fluid and serum for diagnosis of lung cancer.Methods CA-50 of bronchial washings fluid and serum in 49 patients with cancer and 59 patients with benign pulmonary disease was detected by radioimmunoassay method.Results CA-50 of bronchial washings fluid in the patients with lung cancer was much higher than that in the patients with benign pulmonary disease ( P <0 05). CA-50 of serum in the patients with lung cancer was much higher than that in the patients with benign pulmonary disease ( P <0.05). CA-50 of bronchial washings fluid was much higher than that of serum in the patients with lung cancer ( P <0.001). CA-50 of bronchial washings fluid was much higher than that of serum in the patients with benign pulmonary disease( P <0.001).Conclusion When CA-50 level is rising in both washings fluid and serum, it is helpful to diagnose lung cancer. Measuring CA-50 may have certain meaning to supervise lung cancer.