玉叶解毒颗粒抗甲1型流感病毒的作用

Anti-influenza A virus effect of Yuye detoxification particles

目的:研究玉叶解毒颗粒体内外抗甲1型流感病毒(Influenza virus)作用。方法:体内试验检测玉叶解毒颗粒对小鼠感染流感病毒所致肺炎的抑制作用和死亡保护;体外实验通过对狗肾细胞(MDCK)的培养,探讨玉叶解毒颗粒在细胞上对感染流感病毒的抑制作用。结果:玉叶解毒颗粒对小鼠肺内的流感病毒有一定的清除作用,能减轻小鼠肺内的炎性病变,在剂量为15g.kg-1时对小鼠有死亡保护作用,体外实验在125g.L-1时能抑制流感病毒。结论:玉叶解毒颗粒在体内外具有明显的抗流感病毒作用。

OBJECTIVE To investigate the inhibitory effect of Yuye detoxification particles on influenza A virus in vivo and in vitro. METHODS In vivo, the effect of Yuye detoxification particles inhibiting mice pneumonia was evaluated. While in vitro, the influences of Yuye detoxification particles inhibiting influenza A virus in culture MDCK was explored. RESULTS Yuye detoxification particles could eliminate the virus in mice lung,it also alleviated the inflammatory lesions of the mice lung. Furthermore it could inhibit influenza A virus when the nontoxic concentration was 125 g·L^-1. CONCLUSION Yuye detoxification particles might inhibit influenza A virus in vivo and in vitro.