尼卡地平雾化吸入治疗小儿肺炎及并发心力衰竭的疗效探讨

Treatment of infant pneumonia and its complicated heart failure by nicardipine inhalation

目的探讨尼卡地平雾化吸入对小儿肺炎及并发心力衰竭的疗效。方法小儿肺炎８５例、并发疑似心衰３０例、并发心衰２４例，分别随机分成治疗组和对照组。各治疗组雾化吸入尼卡地平，各对照组雾化吸入α糜蛋白酶，疗程均３～５天。结果肺炎治疗组症状体征消失天数、经皮氧饱和度上升及Ｘ线胸片阴转率与对照组相比有显著性差异；疑似心衰治疗组４８ｈ缓解率优于对照组，有显著性差异；心衰治疗组症状体征消失时间、心率减慢、经皮氧饱和度上升均优于对照组，有显著性差异。结论尼卡地平雾化吸入对治疗小儿肺炎、防治并发心力衰竭具有良好的效果。

Objective To study the effect of treatment infant pneumonia and its complicated heart failure by nicardipine inhalation.Methods There were 85 cases of infant pneumonia,30 cases complicated undefined heart failure and 24 cases complicated heart failure divided into two groups by random:the treatment and control.Patients in treating group were given aerosol nicardipine 0 5～1mg/(kg·d) while the control group by aerosol α-chymotrypsin for 3～5 days.Results There were apparent differences in shortening of the time interval of symptoms and signs,in rising of percutaneous TcSaO 2 and in decreasing of negative rate of chest X-ray between the two groups.It was also the same with the undefined heart failure in rate alleviated in 48 hours.The treatment group was superior to the control in disappearance of symptoms and signs,lowing of heart rate and higher percutaneous TcSaO 2.Conclusion It was effective to apply nicardipine inhalation to treat infant penumonia and prevent its complication.