摘要
目的探讨大肠癌黏蛋白1（MUC1）与β-连环素（β-catenin）表达的临床意义。方法应用免疫组织化学法检测90例大肠癌标本MUCl与β-catenin表达，分析两种分子标志的分布类型与大肠癌临床病理的关系；进一步检验MUC1表达与β-catenin分布的关系，评价联合表达对临床预后的判断价值。结果54．44％出现MUC1极性分布的丧失，与肿瘤浸润深度相关（P〈0．05），而58．89％出现B．catenln核转移，与大肠癌TNM分期有关（P〈0．05）。MUC1与核β-catenin的联合表达与大肠癌淋巴结转移和TNM分期相关（P〈0．01）；联合表达阳性者生存率显著低于阴性者（P〈0．05）。结论MUC1极性分布的丧失与β-catenin核转移相关，两者联合表达的阳性提示较差的临床预后。
Objective To investigate the clinical significance of combined expression of mucin 1 （MUC1） and β-catenin in colorectal cancer. Methods Ninety colorectal cancer specimens were subjected to immunohistochemistry for detection of MUC1 and β-catenin. The relationships of expression patterns of these two biomarkers and clinicopathological parameters and survival were analyzed. Results Loss of polarity distribution of MUC1 was detected in 54. 44% cases and was related to depth of invasion （ P 〈0. 05）, and nuclear translocation of β-catenin was found in 58. 89% cases and correlated with TNM stage （P 〈 0. 05 ）. The combined expression of MUC1 and nuclear β-catenin was related to lymph node metasta sis and TNM stage （ P 〈 0. 01 ） and also, a significantly lower survival rate （ P 〈 0. 05 ）. Conclusion Combined expression of MUC1 and nuclear β-catenin indicated a worse prognosis in colorectal cancer.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2011年第1期12-14,161,共4页
Chinese Journal of Experimental Surgery
基金
上海市卫生局局级课题（2008153）
