冠心病患者血β2微球蛋白水平与冠状动脉病变相关性研究

Relationship between β2 microglobulin and coronary artery disease

目的了解冠心病患者肾功能与冠心病的关系。方法选择189例行冠状动脉造影的患者，按冠状动脉病变不同程度分为正常对照组和冠心病组（包括单支病变组、双支病变组、多支病变组），检测各组患者的血β2微球蛋白、尿素氮、肌酐浓度，比较分析不同组别β2微球蛋白、尿素氮、肌酐浓度的差异及其与冠状动脉病变的关系。结果冠心病组陡微球蛋白浓度（2．4±1．3）mg／L高于正常对照组（1．9±0．5）mg／L，二者比较差异有统计学意义（P〈0．05）。β2微球蛋白浓度正常对照组、单支病变组、双支病变组、多支病变组，分别为（1．9±0．5）mg／L，（2．2±0．7）mg／L，（2．4±1．0）mg／L，（3．0±1．8）mg／L，差异有统计学意义（P〈0．05）。结论血β2微球蛋白浓度在冠心病患者中明显升高，提示与冠状动脉病变支数有相关性。

Objective To explore the relationship between renal function and coronary heart disease（CHD） in patients with coronary heart disease. Methods One hundred and eighty -nine patients underwent coronary angiography, according to different degrees of coronary artery disease were divided into normal control group and the CHD group （including single vessel disease, double vessel disease, multi -vessel disease） , detected the blood of β2 microglobulin, urea nitrogen, creatinine concentration, and β2 microglobulin, urea nitrogen, differences of creatinine concentration were compared in different groups, and analysed the relationship with coronary artery disease. Results In CHD group, β2 micro- globulin concentration [ （2.4 ± 1.3） mg/L] was higher than that in control group [ （ 1.89 ±0.53） mg/L], the difference was statistically significant. β2 -microglobulin concentration in normal control group, single- vessel disease, double vessel disease, and multi -vessel disease group [ （1.89 ± 0.53）mg/L, （2. 16 ±0.72） rag/L, （2.37 ±0.97） mg/L, （2.97 ±1.84） mg/L] had statistical differences（ P 〈 0. 05 ）. Conclusions The serum β2 - microglobulin concentration is significantly higher in patients with coronary heart disease, suggesting that it is correlated with the number of coronary vessel disease.