结肠靶向性高分子——甲基丙烯酸甲酯—甲基丙烯酸共聚物理化性质的研究

Colontargeting polymers a study of physical and chemical properties of PMMAcoMAA

目的：制备具有不同酸值的甲基丙烯酸甲酯甲基丙烯酸共聚物（ＰＭＭＡｃｏＭＡＡ），研究其理化性质以便评估其结肠靶向性。方法：以ＰＭＭＡｃｏＭＡＡ薄膜为对象，研究薄膜的水渗透性、溶胀性、临界溶解ｐＨ和在不同ｐＨ缓冲液中的稳定性。结果：ＰＭＭＡｃｏＭＡＡ的理化性质差异是它们的酸值不同导致的，ＰＭＭＡｃｏＭＡＡ酸值越小，其临界溶解ｐＨ越大。结论：ＰＭＭＡｃｏＭＡＡ的理化性质取决于它们的酸值大小。

BJECTIVE: Several copovymers of methyl methacrylate (MMA) and methacrylic acid(MAA) as potential coatings for colon delivery.HZMETHODS: Water vapor transimission,swelling characteristics,in vitro dissolution and stability in function of pH were investigated using the technique of isolated films. RESULTS: The data presented demonstrate relative differences in physicochemical characteristics duo to differences in acid value.The lower acid value is ,the higher critical dissolution pH is. CONCLUSION: The physicochemical properties of PMMAcoMAA are highly influenced by their acid values.