新生儿先天性心脏病血清一氧化氮、血浆内皮素-1及血管紧张素Ⅱ水平的研究

Study the level of serum nitrogen monoxidum, plasmic endothelin-1 and angiotensin Ⅱ in newborn infant with congenital heart diseases

目的观察血清一氧化氮（NO）、内皮素-1（ET-1）及血管紧张素Ⅱ（AngⅡ）在新生儿先天性心脏病中的含量变化，探讨血清NO、ET-1及AngⅡ与新生儿先天性心脏病的关系。方法选择70例患先天性心脏病的新生儿，另选取年龄及性别与之相匹配的体检正常新生儿30例作为对照组。用硝酸还原酶法测定血清NO含量，用放射免疫分析方法检测血浆中的ET-1及AngⅡ含量。结果患先天性心脏病的新生儿组血清NO含量明显低于对照组，而血浆中的ET-1及AngⅡ含量明显高于对照组。结论NO、ET-1及AngⅡ可能参与了先天性心脏病的发生、发展过程。

Objective To detect the level of serum nitrogen monoxidum （NO）, plasmic endothelin-1 （ET- 1）and angiotensin; angiotensin Ⅱ （Ang Ⅱ ） in newborn infant with congenital heart diseases, the relationship between NO and congenital heart diseases has been studied. Methods The 70 cases of newborn infant with congenital heart diseases were selected, simultaneously 30 cases of normal newborn infant with matching age and sex as control. The level of NO was detected with radioimmunoassay. The level of ET-1 and Ang Ⅱ were detected with radioimmunoassay. Results The level of NO was obviously decreased in groups with congenital heart diseases than the normal groups. The level of ET-1 was obviously increased in groups with congenital heart diseases than the normal groups. The contents of Ang Ⅱ was obviously increased in groups with congenital heart diseases than the normal groups. Conclusion NO, ET-1 and Ang Ⅱpossible participate the development in congenital heart diseases.