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阿尔茨海默氏病研究进展 被引量：2

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摘要 阿尔茨海默氏病,俗称老年性痴呆,是常见的神经退行性疾病。近年来关于该病的病因和治疗取得了不少突破性的进展,本文对此作一介绍。
作者 程诗萌 刘建英 冷大亮 张艺瑶 高良才
机构地区 华东师范大学生命科学学院
出处 《生物学教学》 北大核心 2011年第1期8-10,共3页 Biology Teaching
基金 国家大学生创新性实验计划项目081026907 上海大学生创新活动项目:KY2010-16S资助
关键词 阿尔茨海默氏病 乙酰胆碱 Beta-淀粉样蛋白
分类号 R749.1 [医药卫生—神经病学与精神病学]
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参考文献10

  • 1Srivareerat M, Tran Tr, Salim S, et al. 2009. Chronic nicotine restores nomad Aβ levels and prevents short - term memory and E - LTP impairment in Aβ rat model of Alzheimer' s disease. Neurebiology of Aging,7324(4) :1 - 11.
  • 2lwata N, Tsubuki S,Takaki Y, et al. 2001. Metabolic regulation of brain Abeta by neprilysin . Science, 292(5521 ) :1550 - 1552.
  • 3许志强,周华东,蒋晓江.淀粉样β蛋白沉淀及其神经毒性与阿尔茨海默病[J].中国临床康复,2006,10(14):138-140. 被引量：11
  • 4Zhong SZ, Ge QH, Li Q, et al. 2009. Peoniflorin attentuates Aβ (1 - 42 ) - mediated neurotoxicity by regulating calcium homeostasis and ameliorating oxidative stress in hippocampus of rats. Journal of the Neurological Sciences, 280 ( 1 , 2) :71 - 78.
  • 5Corder EH, Saunders AM, Strittmatter WJ, et al. 1993. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science, 261 (5123) :921 -923.
  • 6Strittmatter WJ, Saunders AM, Schmechel D, et al. 1993. Apolipopmtein E: high -avidity binding to β-mnyloid and increased frequency of type 4 allels in late - onset familial Alzheimcr ' s disease apolipoprotein. Proceedings of the National academy of Sciences of the United States of America, 90(5) : 1977 - 1981.
  • 7Coyle JT, Price DL, Delong MR. 1983 Alzheimers'disease:a disorder of conical cholinergic inner'cation . Science, 219 (4589) : 1184 - 1190.
  • 8邱瑜,陈红专,金正均.毒蕈碱受体激动剂治疗阿尔茨海默病的研究进展[J].国外医药（合成药．生化药．制剂分册）,2000,21(6):324-327. 被引量：3
  • 9Avery EE, Baker LD, Asthana S. 1997. Potential role of muscarinic agonists in Alzheimer's disease. Drugs and Aging, 11 (6) 450 - 459.
  • 10Solomon B, Koppel R, Frankel D, et al. 1997. Disaggregation of Alzheimer betaamyloid by site -directed mAb. Proceedings of the National Academy of Sciences of the United States of America, 94 (8) :4109 -4112.

二级参考文献29

  • 1Iwata N,Tsubuki S,Takaki Y,et al. Metabolic regulation of brain Abeta by neprilysin.Science 2001;292(5521):1550-2
  • 2Kuo YM, Emmerling MR, Woods AS,et al. Isolation, chemical characterization, and quantitation of A beta 3-pyroglutamyl peptide from neuritic plaques and vascular amyloid deposits.Biochem Biophys Res Commun 1997;237(1):188-91
  • 3Dickson DW. The pathogenesis of senile plaques.J Neuropathol Exp Neurol1997;56(4):321-39
  • 4Nicoll JA, Yamada M, Frackowiak J, et al. Cerebral amyloid angiopathy plays a direct role in the pathogenesis of Alzheimer's disease. Pro-CAA position statement. Neurobiol Aging 2004;25(5):589-97
  • 5Alvarez AR, Godoy JA, Mullendorff K, et al. Wnt-3a overcomes beta-amyloid toxicity in rat hippocampal neurons.Exp Cell Res 2004;297(1):186-96
  • 6Tamagno E, Robino G, Obbili A, et al. H2O2 and 4-hydroxynonenal mediate amyloid beta-induced neuronal apoptosis by activating JNKs and p38MAPK. Exp Neurol 2003;180(2):144-55
  • 7Prasad KN,La Rosa FG,Prasad JE.Prostaglandins act as neurotoxin for differentiated neuroblastoma cells in culture and increase levels of ubiquitin and beta-amyloid.In Vitro Cell Dev Biol A nim 1998;34(3):265-74
  • 8UedaK,Shinohara S,Yagami T,et al.Amyloid beta protein potentiates Ca2+ influx through L-type voltage-sensitive Ca2+ channels: a possible involvement of free radicals.J Neurochem 1997;68(1):265-71
  • 9Barkats M,Millecamps S,Abrioux P,et al. Overexpression of glutathione peroxidase increases the resistance of neuronal cells to Abeta-mediated neurotoxicity.J Neurochem 2000;75(4):1438-46
  • 10Lovell MA, Ehmann WD, Butler SM, et al. Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease.Neurology 1995;45(8):1594-601

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生物学教学
2011年 第1期

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