胸腺素α1辅助治疗慢性肝衰竭败血症疗效研究

Effect of thymosin alpha l on septicemia in patients with chronic liver failure

目的观察胸腺素α1治疗慢性肝衰竭合并败血症的疗效。方法 64例慢性肝衰竭合并败血症患者分为治疗组和对照组各32例。对照组行常规综合治疗,治疗组在此基础上加用胸腺素α1,每次1.6mg,皮下注射,隔日1次。结果治疗14d后,治疗组疗效显著高于对照组(χ2=5.54,P<0.01),治疗后两组外周血象均较治疗前有明显降低,但治疗组降低更显著(P<0.05)。治疗组CD4+、CD8+水平升高,有统计学意义(P<0.05)。结论胸腺素α1综合治疗法治疗慢性肝衰竭合并败血症疗效优于单纯综合治疗方法 。

Objective To observe the effect of thymosin alpha-1（Tα1） on septemia in patients with chronic liver failure.Methods Sixty-four patients with chronic liver failure accompanying septicemia were randomly divided into treatment group（n=32） and control group（n=32）.Patients in control group received routine comprehensive treatment and patients in treatment group received routine comprehensive treatment plus subcutaneous injection with Tα1（1.6mg every other day）.Results After two weeks of treatment,the curative effect was much better in treatment group than in control group（χ2=5.54,P0.01）,and the number of white blood cells（WBC） and neutrophils was significantly less after treatment than before treatment in both groups,especially in treatment group（P0.05）.The serum CD4＋ and CD8＋ levels were significantly higher in treatment group than in control group（P0.05）.Conclusion Tα1 therapy has a better effect on septicemia in patients with chronic liver failure is better than simple comprehensive therapy.