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C型凝集素受体CLEC-2的研究进展 被引量：2

Advances on the study of CLEC-2, a new C-type lectin receptor
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摘要 C型凝集素样受体-2（CLEC-2）是一个非经典型的c型凝集素受体，主要表达在血小板、中性粒细胞等细胞表面，在马来西亚蝮蛇蛇毒蛋白rhodocytin和跨膜唾液酸糖蛋白podoplanin等相关配体的刺激下，能通过细胞质尾部的YXXL结构域形成二聚体，从而激活syk依赖的信号传导。最近有很多研究显示：CLEC-2在血小板活化聚集、肿瘤转移、血栓形成以及HIV在体内扩散中起着重要的作用。因此，对CLEC-2的进一步研究有利于为血小板相关疾病的治疗提供新的思路和理论指导。 C-type lectin-like receptor-2 （CLEC-2） is a nonclassical C-type lectin receptor, which is mainly expressed on platelets and granulocytes. Under stimulation of the snake venom protein rhodocytin and trans- membrane sialoglyeoprotein podoplanin, it can form a dimer through YXXL motif in the cytosolic tail, leading to a syk-dependent signaling pathway. Recent studies demonstrated that CLEC-2 plays an important role in platelet aggregation, tumor metastasis, thrombotic development, as well as HIV dissemination. Therefore, Further stud- y of CLEC-2 may provide information on the clinical treatment of the diseases related with platelet.
作者 陈妍洁 张艳 沈辰
机构地区 复旦大学上海医学院基因中心
出处 《国际免疫学杂志》 CAS 北大核心 2011年第1期12-15,31,共5页 International Journal of Immunology
基金 国家自然科学基金资助项目（30900266） 高等学校博士学科点专项科研基金资助课题（20090071120053） 医学人才培养模式创新实验区（[2007]29号）
关键词 C型凝集素受体 C型凝集素样受体-2 C-type lectin receptor C-type lectin-like receptor-2
分类号 R392 [医药卫生—免疫学]
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参考文献23

  • 1Colonna M, Samaridis J, Angman L. Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells. Eur J Immunol, 2000, 30 (2) : 697-704.
  • 2Suzuki-Inoue K, Fuller GL, Garcia A, et al. A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2. Blood, 2006, 107(2) : 542-549.
  • 3Kerrigan AM, Dennehy KM, Mourao-Sa D, et al. CLEC-2 is a phagocytic activation receptor expressed on murine peripheral blood neutrophils. J Immunol, 2009, 182(7) : 41504157.
  • 4Xie J, Wu T, Guo L, et al. Molecular characterization of two novel isoforms and a soluble form of mouse CLEC-2. Biochem Biophys Res Commun, 2008, 371(2): 180-184.
  • 5Fuller GL, Williams JA, Tomlinson MG, et al. The C-type lectin receptors CLEC-2 and Dectin-1, but not DC-SIGN, signal via a novel YXXL-dependent signaling cascade. J Biol Chem, 2007, 282 ( 17 ) : 12397-12409.
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  • 7Suzuki-Inoue K, Ozaki Y, Kainoh M, et ah Rhodoeytin induces platelet aggregation by interacting with glycoprotein Ia/IIa ( GPIa/ IIa, Integrin alpha 2 beta 1 ). Involvement of GPIa/IIa-assoeiated src and protein tyrosine phosphorylation. J Biol Chem, 2001,276 (2) : 1643-1652.
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国际免疫学杂志
2011年 第1期

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