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microRNA在固有免疫调控中作用的研究进展 被引量：5

Progress of the stady on microRNA in regulating innate immunity
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摘要 microRNA（miRNA）是一类内源性的短链非编码RNA分子，能与特定的信使RNA靶向结合，在转录后水平调控基因表达。miRNA可在多个环节参与调控机体固有免疫反应。微生物感染时，miRNA可通过调控模式识别受体信号通路及产生的细胞因子，负性或正性调控固有免疫应答。在病毒感染时，宿主编码的miRNA能抑制病毒复制，而病毒利用自身编码的miRNA靶向结合宿主或病毒基因，干扰宿主抗病毒反应，甚至可以利用宿主编码的miRNA促进病毒自身复制。miRNA也参与调节银屑病、哮喘、风湿性关节炎等慢性炎性疾病，因此miRNA可能成为炎性疾病的一个侯选治疗靶点。 microRNA（miRNA） are endogenous small noncoding RNAs that post-transcriptionally regulate gene expression by targeting specific messenger RNAs. miRNA play negative or positive roles in innate immunity by regulating pattern recognition receptor signaling and ensuring cytokine response. Some miRNA en- coded by host can inhibit the invasion and replication of viruses. On the other hand, miRNA encoded by viruses can also interfere with anti-viral defense by targeting viral genes or host genes. Sometimes viruses facilitate self replication using miRNA encoded by host . In addition, miRNAs are involved in the regulation of chronic inflammatory diseases , such as psoriasis, asthma and rheumatoid arthritis. Therefore miRNA might be the potential therapeutic targets of inflammatory diseases.
作者 孙义锡 周俊
机构地区 浙江大学医学院生殖遗传实验室浙江大学医学院细胞生物学系
出处 《国际免疫学杂志》 CAS 北大核心 2011年第1期16-20,共5页 International Journal of Immunology
基金 国家自然科学基金资助项目（30300187 30971505） 浙江省自然科学基金（Y206036）
关键词 MICRORNA 固有免疫 细胞因子 microRNA Innate immunity Cytokines
分类号 R3 [医药卫生—基础医学]
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参考文献26

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二级参考文献16

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共引文献1

同被引文献55

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引证文献5

二级引证文献19

国际免疫学杂志
2011年 第1期

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