Th17细胞与Graves’病

Advancement of Thl7 lymphocyte in Graves＇ disease

Th17细胞是近几年研究发现的一类不同于Th1和Th2细胞亚群的新型CD4^＋效应T细胞。该类细胞是由天然T细胞前体分化而来，具有独立分化和发育调节机制，在其分化过程中需要IL-6和转化生长因子。B、转录因子RORα及STAT3等的参与，主要分泌IL-17A、IL-17F、IL-22等多种细胞因子，并参与多种炎症、自身免疫性疾病的发生和发展。Graves’病（GD）是一种器官特异性自身免疫病，Th2细胞介导的体液免疫在其发病中起着重要作用。近来有研究提示IL-23／Th17轴亦参与GD的发展。因此了解Th17细胞分化的影响因素、产生的细胞因子以及在免疫性疾病GD中的作用具有重要的临床意义。

Recent studies have defined a new subset of the CD4^＋ T-cell effectors the Th17 lineage, which is derived from nature T cell precursor and distinct from Thl and Th2. It possesses independent regulatory mechanisms of differentiation and development. Some factors, such as the unique combination of interleukin-6 and transforming growth factor-β, Orphan nuclear receptor-γt, signal transducer and activator of transcription 3 are required for the differentiation of Th17 cell, resulting in the production of the signature cytokines interleukin-17A,IL-17F, and IL-22, etc. Th17 plays an important function in the host-defense-response, but also has become notorious for its role in the pathogenesis of many autoimmune diseases. Graves＇ disease （GD） is an organ-specific autoimmune disease, in the pathogenesis of which Th2 plays an important role. Recently, the IL-23/Th17 axis and its subsequent response have been found to take part in both develpment and maintenance of GD. Studying the effect factors on the differentiation of ThlT, the cytokines profiling, the function of the cell lineage involved in GD is extremely significant.