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γ-干扰素诱导蛋白10与风湿性疾病关系的研究进展 被引量：1

Progress on the study of the relationship between IP - 10 and rheumatic diseases
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摘要 γ-干扰素诱导蛋白10（IP-10）是CXC类趋化因子之一，CXCR3是其唯一受体。研究表明：IP-10具有重要的生物学功能，参与多种疾病的发生，与多种风湿性疾病关系密切，主要介导Th1型炎症反应，还可抑制新生血管形成。另外，测定IP-10水平也可对某些风湿性疾病进行活动度评价、预后判断以及治疗决策指导。 IP-10 is a member of the CXC chemokine family. CXCR3 is the unique receptor of IP-10. Studies have shown that IP-10 is involved in rheumatic diseases by mediating Th1-type inflammatory response and inhibiting angiogenesis. In addition, detecting the level of IP-10 can be helpful in the assessment of the activity of certain rheumatic diseases, and guide the evaluation of the disease progression and deseision-making for the treatment.
作者 邹宗毅 唐雪梅
机构地区 重庆医科大学附属儿童医院肾脏免疫科
出处 《国际免疫学杂志》 CAS 北大核心 2011年第1期65-68,80,共5页 International Journal of Immunology
关键词 γ-干扰素诱导蛋白10 系统性红斑狼疮 类风湿关节炎 幼年特发性关节炎 IP-10/CXCL10 Systemic lupus erythematosus Rheumatoid arthritis Juvenile idiopathic arthritis
分类号 R593 [医药卫生—内科学]
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参考文献25

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共引文献4

同被引文献9

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国际免疫学杂志
2011年 第1期

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