摘要
综述HtrA1丝氨酸蛋白酶的结构、功能、在正常组织和器官中的表达,以及在年龄相关性黄斑病变、妊娠期高血压疾病、恶性肿瘤、骨关节炎等相关疾病中的最新进展。加强对HtrA1丝氨酸蛋白酶的研究,以了解更多的生物学功能和分子机制,为广泛的临床实践提供理论依据。
出处
《肝胆胰外科杂志》
CAS
2010年第6期525-528,共4页
Journal of Hepatopancreatobiliary Surgery
参考文献28
-
1Bowden M A,Di Nezza L A,Jobling T,et al.Expression of HtrA1,2 and 3 in human endometrial cancer[J].Reproduction,Fertility and Development,2004,16(Suppl):284-284.
-
2Clausen T,Southan C,Ehrmann M.The HtrA family of proteases:implications for protein composition and cell fate[J].Mol Cell,2002,10(3):443-455.
-
3Spiess C,Beil A,Ehrmann M.A temperature-dependent switch from chaperone to protease in a widely conserved heat shock protein[J].Cell,1999,97(3):339-347.
-
4Lipinska B,Zylicz M,Georgopoulos C.The HtrA (DegP) protein,essential for Escherichia coli survival at high temperatures,is an endopeptidase[J].J Bacteriol,1990,172 (4):1791-1797.
-
5Nie GY,Hampton A,Li Y,et al.Identification and cloning of two isoforms of human high-temperature requirement factor A3 (HtrA3),characterization of its genomic structure and comparison of its tissue distribution with HtrA1 and HtrA2[J].Biochem J,2003,371(Pt 1):39-48.
-
6van Loo G,van Gurp M,Depuydt B,et al.The serine protease OMI/HtrA2 is released from mitochondria during apoptosis.OMI interacts with caspase-inhibitor XIAP and induces enhanced caspase activity[J].Cell Death Diff,2002,9(1):20-26.
-
7Chien J,Staub J,Hu SI,et al.A candidate tumour supressor HtrA1 is downregulated in ovarian cancer[J].Oncogene,2004,23(8):1636-1644.
-
8Zumbrunn J,Trueb B.Primary structure of a putative serine protease specific for IGF-binding proteins[J].FEBS Lett,1996,398(2-3):187-192.
-
9Hu SI,Carozza M,Klein M,et al.Human HtrA,an evolutionarily conserved serine protease identified as a differentially expressed gene product in ostcoarthtitic cartilage[J].J Biol Chem,1998,273(51):34406-344 12.
-
10De Luca A,De Falco M,Severino A,et al.Distribution of the Serine Protease HtrA1 in Normal Human Tissues[J].J Histochemistry Cytochemistry,2003,51(10):1279-1284.
同被引文献13
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1郭娜,宗璐,苟文丽.HtrA1在妊娠期高血压疾病患者胎盘组织中的表达[J].中国妇幼健康研究,2008,19(2):104-106. 被引量:2
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2刘海意,刘玉凌,乔福元.正常妊娠与子痫前期胎盘VEGF及其受体mRNA差异表达的研究[J].中国妇幼保健,2008,23(12):1707-1709. 被引量:6
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3王强,崔艳双,马艳,王巍,王冰.子痫前期、子痫患者胎盘组织中VEGF的表达及其与MVD的相关性研究[J].中国实用医药,2008,3(17):18-19. 被引量:1
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4李扬,苟文丽.HtrA1生物学功能及与早发型重度子痫前期的相关性[J].现代妇产科进展,2010,19(11):868-870. 被引量:2
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5袁媛,周静,姜政.核心蛋白聚糖生物学的研究进展[J].医学综述,2011,17(9):1303-1306. 被引量:6
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6宗璐,苟文丽,郭娜.HtrA1和TGF-β1在妊娠期高血压病患者胎盘中的表达[J].西安交通大学学报(医学版),2011,32(3):355-358. 被引量:11
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7张建莹,朱启英.早发型重度子痫前期发病机制及监测的研究新进展[J].中国优生与遗传杂志,2012,20(9):125-126. 被引量:1
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8李春芳,苟文丽,宗璐,邵文裕,李扬.HtrA1在正常孕妇血清及胎盘组织中的表达及其意义[J].西安交通大学学报(医学版),2013,34(1):98-100. 被引量:3
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9贺晓菊,辛思明,刘淮.血管内皮生长因子及其受体家族与子痫前期发病的关系[J].中华围产医学杂志,2014,17(1):65-67. 被引量:7
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10刘玲艳,张学勤.子痫前期发病机制的研究进展[J].医学综述,2015,21(3):490-491. 被引量:27