摘要
PhoP-PhoQ是调控沙门菌毒力的重要双组分信号转导系统,由组氨酸蛋白激酶PhoQ和反应调节蛋白PhoP组成。PhoP-PhoQ可调节沙门菌对Mg2+及其他周质环境的适应性,并调控沙门菌感染中毒力基因的转录和表达。PhoP-PhoQ调控的毒力基因参与沙门菌对上皮细胞的侵袭、胞内生存、对抗菌肽的抵抗反应、脂质A的修饰、Ⅲ型分泌系统效应蛋白的分泌等环节。PhoP-PhoQ还可与其他双组分信号转导系统或调节子合作,调控沙门菌的毒力。因此,PhoP-PhoQ双组分信号转导系统在沙门菌的毒力调控中发挥重要作用。
In Salmonella,the PhoP-PhoQ two-component signal transduction system （TCS） is a major regulator of virulence,consisting of the trans-membrane sensor,PhoQ,and the cytoplasmic regulator,PhoP. PhoP-PhoQ can regulate Salmonella adaption to a low Mg2＋ environment and other periplasmic signals,mediating transcription and expression of genes that encode proteins essential to bacterial virulence in the host cell. PhoP-PhoQ is necessary for Salmonella in epithelium cell invasion,survival within macrophages,resistance to antimicrobial peptides,modification of lipid A,function of type Ⅲ secretion system,and pathogenesis. PhoP-PhoQ can also interact with other TCSs or regulators to form a perfect regulative network to ensure the regulation more suitable and well-rounded. Therefore,PhoP-PhoQ plays an important role in the regulation of Salmonella virulence.
出处
《微生物与感染》
2010年第4期239-242,共4页
Journal of Microbes and Infections
基金
复旦大学青年科学基金(09FQ43)
