肿瘤坏死因子-α基因-238位点多态性与梅毒易感性的关系

Association of tumor necrosis factor-α-gene-238 single nucleotide polymorphism with susceptibility to syphilis

目的: 评价肿瘤坏死因子-α基因-238位点G、A单核苷酸多态性与梅毒遗传易感性的关系。方法:应用实时荧光定量PCR技术检测56例早期显性梅毒患者、38例早期潜伏梅毒患者和102例正常人对照组TNF-α基因-238位点G、A单核苷酸多态性。结果:早期梅毒组TNF-α基因-238位点G、A等位基因的分布频率分别为0.968、0.032,对照组分布频率分别为0.975和0.025,两组相比无显著差异(P=0.657);显性梅毒组TNF-α基因-238位点G、A等位基因的分布频率分别为0.973和0.027,潜伏梅毒组分布频率分别为0.961和0.039,两组相比无显著差异(P=0.114)。结论:TNF-α基因-238位点G、A单核苷酸多态性与梅毒遗传易感性可能无显著相关。

Objective： To associate tumor necrosis factor-α - gene - 238 G, A single nucleotide polymorphism with susceptibility to syphilis. Methods： Tumor necrosis factor -α - gene - 238 G, A single nucleotide polymor- phism was detected by real - time quantitative fluorescent PCR in 56 early symptomatic syphilis patients, 38 early latent syphilis patients, and 102 normal controls. Results： Frequency of G, A allele was 0.968 and 0.032 in the early syphilis group, and 0. 975 and 0. 025 in the controls, with no significant difference. Frequency of G, A allele was 0. 973 and 0. 027 in the early symptomatic syphilis group, and 0. 961 and 0. 039 in early latent syphilis group, with no significant difference. Conclusion： Tumor necrosis factor--α- gene - 238 G, A single nucleotide polymorphism was not associated with susceptibility to syphilis.