Gelsolin蛋白与非小细胞肺癌转移的关系

Relationship between Gelsolin expression and metastasis of non-small cell lung cancer

目的:探讨凝溶胶蛋白(Gelsolin)在预测非小细胞肺癌(non-small cell lung cancer,NSCLC)临床病理特征、癌细胞转移和患者预后中的价值。方法:采用SP免疫组化法检测63例有完整资料的NSCLC患者癌组织标本及63例癌旁组织标本Gelsolin蛋白表达,分析Gelsolin与NSCLC患者临床病理特征和转移、预后的关系。结果:Gelsolin蛋白在63例癌旁组织中均为弱阳性表达,在肺癌细胞中的阳性表达率为31.7%(20/63);Gelsolin蛋白阳性表达与NSCLC组织学类型、肿瘤分化程度、肿瘤大小、临床分期及淋巴结转移有关(P<0.05);Kaplan-Meier生存分析显示Gelsolin蛋白阳性患者生存率较Gelsolin蛋白弱阳性或阴性患者为低(P<0.05);Cox风险比例模型显示淋巴结转移及Gelsolin蛋白阳性可显著增加NSCLC患者的死亡风险(P<0.05)。结论:Gelsolin基因在NSCLC发生发展中起重要作用,与NSCLC转移及低生存率有关,可作为临床早期发现NSCLC转移及预测预后的指标。

Objective：To probe the value of Gelsolin in the prediction of the clinicopatho-logical features,metastasis of cancerous cell and prognosis of patients with non-small cell lung cancer（NSCLC）.Methods：SP immunohistochemical was used to detect the expression of Gelsolin protein in 63 lung carcinoma and 20 paracancerous tissue.Results：The positive rate of Gelsolin protein in lung carcinoma was 31.7%（20/63）while the exprssion of lung paracacerous tissues was all weakly positive.In the carcinoma tissues,the positive expression of Gelsolin protein in NSCLC was signifi-cantly related to histotype degree,the degree of differentiation,size of tumor and lymph node metastasis（P0.05）;Kaplan-Meier survival analysis showed that the survival time of Gelsolin positive patients was shorter than that of Gelsolin negative or weakly positive patients（P0.05）;Cox regression analysis revealed that lymph node metastasis and Gelsolin positive expression were the noticeable affective factors on the death of the NSCLC patients after surgery.Conclusion：Gelsolin plays an important role in the development in NSCLC and was associated with transfer and low survival rate in patients with NSCLC,which can be used as an early indicator of NSCLC metastasis and predict-ation of prognosis.