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抑肽酶对体外循环中TNF-α与A-aDO_2及出血的影响

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摘要 目的:探讨抑肽酶对体外循环(cardiopulmonary bypass,CPB)下冠状动脉旁路移植术(coronary artery bypass,CABG)患者肿瘤坏死因子-α(tumor necrosis factorα,TNF-α)与肺泡动脉氧分压差(A-aDO2)以及术后出血的影响。方法:总结40例CPB下行CABG手术患者,20例体外循环期间使用抑肽酶,另外20例体外循环期间未使用抑肽酶,分别检测计算麻醉诱导诱导前、CPB后转机后2h、24 h TNF-α与A-aDO2,统计患者术后引流量。结果:术后出血量为(417±179)mL和(843±228)mL,但差异无显著性(P>0.05)。两组CPB开始后2 h和24 h TNF-α均有明显升高,非抑肽酶使用组较使用组高,差异有显著性(P<0.05)。两组CPB开始后2 h和24 h A-aDO2均有明显升高,差异无显著性(P>0.05)。结论:停止使用抑肽酶后,伴随CPB手术的TNF-α的释放会有所增加,但这种增加并不足以增加对器官功能的损害;停止应用抑肽酶不会引起CPB术后出血的显著增加。
作者 蒋成榜 程德志 姜晓芬 何志锋 张翔 孙成超
机构地区 温州医学院附属第一医院心胸外科
出处 《温州医学院学报》 CAS 2010年第6期589-591,共3页 Journal of Wenzhou Medical College
关键词 体外循环 冠状动脉旁路移植 抑肽酶 全身炎症反应综合征
分类号 R654.1 [医药卫生—外科学]
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参考文献5

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共引文献7

温州医学院学报
2010年 第6期

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